HPV病毒感染与宫颈炎症及宫颈癌之间的关系及意义分析  

The correlation between HPV infection and expression of P16 and E-cadherin in cervical cancer cell lines

作　　者：张婵 孙媛[2] 吴茉莉[2] 孔庆友[2] 陈晓燕[2] 姚媛媛[2] 张朋[2] 

机构地区：[1]大连市妇幼保健院检验科,辽宁大连116033 [2]大连医科大学生物学教研室,辽宁大连116044

出　　处：《中国微生态学杂志》2015年第8期968-970,共3页Chinese Journal of Microecology

基　　金：辽宁省自然科学基金(2013023040)

摘　　要：目的研究人乳头瘤病毒(HPV)在宫颈炎症、宫颈癌前病变及宫颈癌中的水平及临床意义。方法分别选取宫颈炎症278例、宫颈癌前病变174例、宫颈腺癌82例、宫颈鳞癌183例患者,并以218例宫颈无病变的病例作为对照,所有患者均行薄层液基细胞学(TCT)检查及阴道镜下病理活检,检测各组患者间HPV阳性水平并对统计结果加以分析。结果 218例宫颈无病变病例中高危性HPV阳性率为9.6%(21/218),其余717例宫颈出现病变的患者中高危型HPV筛查结果阳性例数为405例,阳性检出率56.5%,且随着宫颈病变严重程度的加重,高危型HPV检出率逐渐升高(P<0.01),但是宫颈腺癌和宫颈鳞癌组的高危型HPV阳性率比较差异无统计学意义(P>0.05)。结论 HPV是宫颈癌前病变及宫颈癌的主要致病因素,对宫颈炎症、宫颈癌前病变及宫颈癌患者行HPV检测对于患者早日确诊及早日治疗具有重要意义。Objective To analyze the level of human papilloma virus（HPV）in cervical inflammations,cervical precancerous lesions and cervical cancers,and discuss its clinical significance.Methods 278 cases of cervical inflammations,174 cases of cervical precancerous lesions,82 cases of cervical adenocarcinomas and 183 cases of cervical squamous cell carcinomas were included;218cases without cervical lesions were selected as the controls.All the patients were performed thin layer liquid based cytology（TCT）examination and pathological biopsy under colposcope;the HPV positive rate in each group was detected,and the results were analyzed.Results The positive rate of high-risk HPV in the control group was 9.6%（21/218）,while that of the other 717 cases with cervical lesions was 56.5%（405/717）which increased along with the severity of cervical lesions（P〈0.01）.However there was no obvious difference in the positive rate of high-risk HPV between the cervical adenocarcinomas group and cervical squamous cell carcinoma group（P〈0.05）.Conclusion HPV is the main pathogenic factor in cervical precancerous lesions and cervical cancer.It is of great significance to detect HPV for early diagnosis and treatment of cervical inflammations,cervical precancerous lesions and cervical cancers.

关 键 词：高危型人乳头瘤病毒 薄层液基细胞学检查 宫颈炎症 癌前病变 宫颈癌 

分 类 号：R373.9[医药卫生—病原生物学]