大肠癌同时性肝转移原发灶切除患者临床病理特征和预后关系分析  

The relationship between clincopathological features and prognosis of colorectal cancer in synchronous liver metastases after resection of the primary tumors

作　　者：朱孟秀 娄长杰[1] 李晓雪[1] 陆海波[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院肿瘤内科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2015年第4期305-310,共6页Practical Oncology Journal

基　　金：留学归国基金（LC2013C27）

摘　　要：目的：分析77例大肠癌同时性肝转移接受原发灶切除患者的临床病理特征和预后的关系。方法对77例经病理证实的大肠癌同时性肝转移接受原发灶切除患者的临床病理特征和预后的关系进行回顾性分析，采用Kaplan－Meier法进行生存分析，Log－rank检验比较组间生存差异。结果性别、肿瘤分化程度、TNM分期与预后显著相关（ P＜0．05）；而年龄、原发肿瘤部位、治疗方式、肝转移灶数目及是否合并肝外转移与预后无相关（ P＞0．05）。术前血清CEA和CA19－9与性别、肿瘤分化程度、TNM分期显著相关（P＜0．001）。 TNM分期与临床病理参数相关性分析结果显示仅原发灶手术方式与TNM分期相关（P＜0．05）。结论男性、肿瘤低分化及Ⅲ期是大肠癌同时性肝转移接受原发灶切除患者的预后不良因素。Objective To analyze the clincopathological features and prognosis of 77 colorectal cancer patients with synchronous liver metastases after resection of the primary tumors.Methods Seventy seven colorec-tal cancer patients with synchronous liver metastases who underwent resection of the primary tumors and patholog-ical confirmed were enrolled in this retrospective study.The clincopathological features and prognosis were ana-lyzed.Kaplan-Meier method was used to analyze survival rate.The differences between survival curves were cal-culated by Log-rank test.Results The analysis showed that sex,tumor differentiation and TNM stage were as-sociated with prognosis（P〈0.05）.The analyses demonstrated no differences in age,primary tumor site,treat-ment,number of liver metastases and extrahepatic metastasis（P〉0.05）.There was a significant correlation be-tween CEA,CA19-9 level and gender,tumor differentiation and TNM stage（P〈0.001）and the corresponding surgical procedure and TNM stage（P〈0.05）.Conclusion The analysis show that male,the low differentiation and stageⅢare poor prognosis factors.

关 键 词：结直肠肿瘤 肝转移 临床病理特征 预后 

分 类 号：R735.3[医药卫生—肿瘤]