国内关于胃癌组织STAT3表达与临床意义的Meta分析  

Meta analysis of the expression and clinical significance of STAT3 in gastric cancer in China

作　　者：王康[1] 白静[2] 

机构地区：[1]包头医学院,内蒙古包头014060 [2]包头市肿瘤医院放疗科

出　　处：《包头医学院学报》2015年第8期12-15,共4页Journal of Baotou Medical College

摘　　要：目的：对信号转导与转录活化因子3（signal transducer and activator of transcription 3,STAT3）在国内胃癌患者肿瘤组织中表达情况及其与临床特征的关系进行系统评价。方法：检索中国学术期刊全文数据库（ CNKI）、中文科技期刊全文数据库（ VIP）、万方数据库（ WANFANG）,并辅以文献追溯的方法,收集国内发表的关于STAT3在胃癌中表达及其临床意义的病例对照研究,检索时间均从建库至2014年10月18日。设定纳入和排除标准,完成文献筛选、资料提取、质量评估,应用RevMan 5.0软件进行Meta分析。结果：共纳入21项研究,其中胃癌组1299例,正常胃黏膜组864例。 Meta分析示：胃癌STAT3表达高于正常胃黏膜,差异具有统计学意义[ OR =15.23,95% CI =（12.00,19.32）, P 〈0.00001]；胃癌低分化、未分化组STAT3表达明显高于高分化、中分化组[ OR =0.31,95% CI =（0.19,0.53）, P 〈0.0001],侵及浆膜组STAT3表达明显高于未侵及浆膜组[ OR =0.24,95% CI =（0.17,0.34）, P 〈0.00001],有淋巴结转移组STAT3表达明显高于无淋巴结转移组[ OR =4.13,95% CI =（3.15,5.42）, P 〈0.00001],Ⅲ~Ⅳ期组STAT3表达明显高于Ⅰ~Ⅱ期组[ OR =0.23,95% CI =（0.13,0.41）, P 〈0.00001]。结论：胃癌中STAT3的高表达具有一定临床意义,对胃癌的早期诊断、治疗及预后判断有重要价值。Objective：To systematically evaluate the expression of signal transducer and activator of transcription 3 （STAT3） in tumor tissue of patients with gastric cancer （ GC） in China and its relationship with clinicopathologic features. Methords：All the case-control studies relevant to the expression and clinical significance of STAT3 in GC published in China were retrieved with the assistance of the literature trace method from CNKI, VIP and Wanfang Database from the establishment date of each database to November 18th, 2014. Literature screening, data extraction and quality assessment were accomplished according to the inclusion and exclusion criteria established, and then meta-analysis was conducted using RevMan 5. 0 software. Results：A total of 21 studies were recruited, which included 1299 cases in the GC group and 864 cases in the normal gastric mucosa group. The results of meta-analysis showed that STAT3 expression in the GC group was higher than that in the normal gastric mucosa group, with a significant difference（ OR =15. 23, 95 % CI =（12. 00,19. 32）, P 〈0. 00001）. STAT3 expression in the non-differentiated and poorly differentiated GC group was significantly higher than that in the moderately and highly differentiated GC group （ OR =0. 31,95% CI =（0. 19,0. 53）, P 〈0. 000 1）. The expression of STAT3 in the group with serosal invasion（ OR =0. 24, 9 % CI =（0. 17,0. 34）, P 〈0. 00001） or lymph node metastasis （ OR =4. 13, 95 % CI =（3. 15, 5. 42）, P 〈0. 00001） was significantly higher than that in the group without serosal in-vasion or lymph node metastasis, respectively. And the expression of STAT3 in the group ofⅢ~Ⅳstage was significantly higher than that in the group ofⅠ~Ⅱstage （ OR =0. 23, 95 % CI =（0. 13, 0. 41）, P 〈0. 00001）. Conslusion：The high expression of STAT3 in GC is of a certain clinicopathologic significance, which is considerably valuable in the early diagnosis, treatment and prognosis of GC.

关 键 词：STAT3 胃癌 META分析 STAT3 

分 类 号：R735.2[医药卫生—肿瘤]