基于气-液剪切的微流控技术制备单分散壳聚糖微胶囊  

Preparation of Uniform Sized Chitosan Microcapsules By Gas-Liquid Microfluidic Technique

作　　者：姚荣沂 王慧萍[1] 陈艳军[1] 陈明[1] 张超灿[1] 

机构地区：[1]武汉理工大学材料科学与工程学院,湖北武汉430070

出　　处：《高分子材料科学与工程》2015年第8期118-122,共5页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(50803048);中央高校基本科研业务专项资金资助项目(WUT:2013-IV-008;2014-zy-001)

摘　　要：在自制的毛细管微流控装置中,采用基于气-液剪切原理的微流控技术制备了尺寸可控的单分散壳聚糖微胶囊。研究了外相气体流速、内相液体流速对微胶囊尺寸和多分散性的影响,并通过光学显微镜、扫描电镜等对微胶囊的尺寸、形态进行了表征。所制备的微胶囊呈规则的球形,大小均一,囊壁致密均匀。随着气体流速的增大,微胶囊的尺寸明显变小。同时,通过气-液微流控技术将荧光物质和磁性纳米粒子包覆在微胶囊的液体内腔中,分别得到具有特征荧光以及磁性的壳聚糖微胶囊。Monodisperse chitosan microcapsules were prepared using gas-liquid microfluidic technique. The effects of gas flow rate and liquid flow rate on the size and size distribution of the microcapsules were studied in detail. The optical microscope and SEM were used to characterize the size and morphology of microcapsules. The results show that the prepared microcapsules are spherical and monodisperse. With the increase of gas flow rate,the size of microcapsules decreases,while the coefficient of variation（ CV） retains within 6%. The liquid flow rate has a little influence on the size of the microcapsules. Gas-liquid microfluidic technique is also applied to embed the fluorescent substances or magnetic nanoparticles into the core of microcapsules,obtaining monodisperse microcapsules with characteristic fluorescence or magnetism.

关 键 词：微胶囊 微流控技术 气-液剪切 壳聚糖 单分散性 

分 类 号：TQ320.669[化学工程—合成树脂塑料工业]