胶体磷(^(32)P)酸铬联合自体毛发辅助栓塞介入治疗28例肝癌的疗效  

Colloidal chromium phosphate combined with autologous hair assisted intervention in treatment of 28 cases of hepatocellular carcinoma

作　　者：李杰[1] 段艳霞[1] 徐心[1] 王志亮[1] 

机构地区：[1]西安交通大学第二附属医院普通外科,西安710004

出　　处：《山西医科大学学报》2015年第8期718-720,共3页Journal of Shanxi Medical University

基　　金：国家自然科学基金资助项目(81172358)

摘　　要：目的探讨新的介入栓塞方法以改善传统肝癌介入栓塞的治疗效果。方法针对中晚期肝癌患者28例,采用常规化疗药物混和放射性胶体32P,同时采用患者自体毛发颗粒进行辅助介入栓塞,观察术后患者临床症状、血清甲胎蛋白及肿瘤体积改变。结果采用此种放射性介入栓塞治疗方法,术后28例患者临床症状缓解,影像学检查有13例肿瘤体积缩小30%-49%,8例患者肿瘤体积缩小超过50%,剩余7例患者术后肿瘤无进展。1年生存率为67.9%,2年生存率为42.9%。结论采用患者自体毛发颗粒联合胶体磷(32P)酸铬,混合碘化油进行放射性栓塞治疗可增加栓塞效果,使得肿瘤体积明显缩小,临床症状缓解,提高生活质量。Objective To explore a novel method of hepatic artery embolization in the treatment of hepatocellular carcinoma（HCC）.Methods Twenty-eight patients with advanced HCC were enrolled and treated with transcatheter arterial chemoembolization （TACE）,and the embolization was improved with radioactive colloidal chromium phosphate 32 and their autologous hair as adjuvants.Changes of the clinical symptom,the serum AFP level,and the tumor volume were observed.Results After treatment,clinical symptoms were relieved in all of 28 cases.Imaging examination showed the tumor volume was reduced by 30％-49％ in 13 cases,more than 50％ in 8 cases,and no progress in other 7 cases.The one-year survival rate was 67.9％,and two-year survival rate was 42.9％.Conclusion Colloidal chromium phosphate combined with autologous hair could improve the effect of embolization,subsequently,reduce the tumor volume,remit the clinical symptom,and improve the life quality.

关 键 词：肝细胞癌 经肝动脉化疗栓塞 磷酸铬微胶粒 自体毛发颗粒 

分 类 号：R735.7[医药卫生—肿瘤]