Fractalkine: multiple strategies to counteract glutamate receptors activation leading to neuroprotection  

作　　者：Clotilde Lauro 

机构地区：[1]Department of Physiology and Pharmacology, Istituto Pasteur Fondazione Cenci Bolognetti, Sapienza University of Rome

出　　处：《Neural Regeneration Research》2015年第8期1214-1215,共2页中国神经再生研究（英文版）

摘　　要：Glutamate（Glu）is the main excitatory amino acid in the brain and plays a pivotal role in many neurophysiological functions.Nevertheless,an excess and prolonged exposure to Glu determines the overactivation of glutamate receptors（Glu Rs）with consequent impairment of cellular calcium（Ca2＋）homeostasis,Glutamate（Glu）is the main excitatory amino acid in the brain and plays a pivotal role in many neurophysiological functions.Nevertheless,an excess and prolonged exposure to Glu determines the overactivation of glutamate receptors（Glu Rs）with consequent impairment of cellular calcium（Ca2＋）homeostasis,

关 键 词：glutamate excitatory impairment homeostasis neuronal Glutamate NMDAR intracellular adenosine microglia 

分 类 号：R741[医药卫生—神经病学与精神病学]