非小细胞肺癌患者检测血清CA21-1、IGF-1表达对术后疗效的评估  

Value of detection of CA21-1 and CA21-1 expression for evaluating the prognosis of patients with non-small cell lung cancer after surgery

作　　者：杜立平[1] 

机构地区：[1]内蒙古医科大学第一附属医院,内蒙古呼和浩特010059

出　　处：《临床肺科杂志》2015年第10期1784-1786,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的研究非小细胞肺癌患者检测血清中细胞角蛋白19片段（CA21-1）、胰岛素样生长因子-1（IGF-1）表达对其术后疗效评估的临床价值与意义。方法选择2014年2月-2015年1月我院收治的非小细胞肺癌患者68例设为观察组，另选68例同期健康体检者为对照组。采取放射免疫分析法（RIA）对治疗前两组IGF-1水平进行测定，ELISA法对血清中CA21-1水平进行测定。观察组治疗后再次对CA21-1、IGF-1水平进行测定。结果治疗前，观察组CA21-1（7．52±1．15）μg／L、IGF-1（259．61±52．25）μg/L显著高于对照组的（1．52±0．17）μg/L、（155．54±21．83）μg／L；且治疗后观察组CA21-1、IGF-1水平显著降低与对照组相比差异无统计学意义；患者CA21-1、IGF-1水平与年龄、性别均无统计学意义（P〉0．05）。观察组CA21-1、IGF-1水平Ⅲ期〉Ⅱ期〉I期〉对照组，差异均有统计学意义（均P〈0．05）。经Spearman相关性分析结果显示，非小细胞肺癌患者CA21-1与IGF-1水平相关系数为：（r=-0．150和r=0．271，均P〉0．05），提示CA21-1与IGF-1浓度无相关性。结论CA21-1与IGF-1浓度与非小细胞肺癌患者的发生及发展密切相关，故两者浓度可作为非小细胞肺癌患者术后疗效评估的参考指标。Objective To explore the value of detection of cytokeratin 19-fragment （ CA21-1 ） and insulin- like growth factor 1 （ IGF-1 ） expression in serum for evaluating the prognosis of patients with non-small cell lung cancer after surgery. Methods From February, 2014 to January, 2015, 68 patients with non-small cell lung cancer were selected as the observation group, and 60 healthy people were taken as the control group at the same time. The level of IGF-I was detected by RIA, and CA21-1 by ELISA between the two groups before and after the treatment. Results Before the treatment, the level of CA21-1 was （7.52 ± 1.15 ） μg/L, and the level of IGF-I was （259. 61 ± 52. 25 ） μg/L in the observation group, which were significantly higher than those of the control group [ （ 1.52± 0. 17）μg/L and （155.54 ±21.83） μg/L] （P 〈0. 05）. There was no significant difference in IGF-1 and CA21-1 after the treatment between the two groups （ P 〉 0.05 ）. The levels of CA21-1 and IGF-1 had no statistical signifi- cance on age and gender （ P 〉 0.05 ）. The levels of CA21-1 and IGF-1 was the highest at stage Ill, followed by stage II and I in the observation group （ all P 〈 0.05 ）. The Spearman correlation analysis results showed that the correla- tion coefficient of CA21-I and IGF-1 levels was r =0. 150 and r =0. 271 in NSCLC patients （P 〉0.05）, which re- flected CA21-1 and IGF-1 had no relevance. Conclusion The levels of CA21-1 and IGF-1 are closely related with the occurrence and development of NSCLC, so they can be used as important reference indexes to evaluate the prog- nosis of NSCLC patients.

关 键 词：非小细胞肺癌 CA21-1 IGF-1 疗效评估 

分 类 号：R734.2[医药卫生—肿瘤]