预防性应用咖啡因防治超低出生体重儿呼吸暂停的疗效观察  

Prophylactic efficacy of caffeine in the prevention of apnea in low birth weight children

作　　者：翟娜 齐卫斌[2] 魏江玲 张军华 曹巧娜 魏彦敏 邱静静[2] 冯敬普 

机构地区：[1]无极县医院,河北无极052460 [2]石家庄市第四医院,河北石家庄050011

出　　处：《临床肺科杂志》2015年第10期1867-1869,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨预防性应用咖啡因防治超低出生体重儿呼吸暂停的临床效果,以期降低新生儿并发症发生率。方法选取90例超低出生体重儿为研究对象,按住院号单双分成两组,对照组45例,予氨茶碱预防呼吸暂停,观察组45例,予以咖啡因预防呼吸暂停,观察治疗后在呼吸暂停发生率和相关指标变化。结果对照组在出生后10 d内、胎龄32周前呼吸暂停发生率分别为42.22%、48.89%,观察组相对应的分别为11.11%、13.33%,两组比较差异有统计学意义(P<0.05);两组治疗后吸氧时间、体重增加至2 kg日龄,住院时间,机械通气发生率,硬肿症、败血症、颅内出血等并发症发生率、β-内啡肽水平比较差异均有统计学意义(P均<0.05);在空腹血糖、钾、动脉血氧分压、动脉血二氧化碳分压、动脉血氧饱和度比较均无统计学意义(P均>0.05)。结论咖啡因能有效防治超低出生体重儿呼吸暂停发生率,且安全性好。Objective To investigate the prophylactic efficacy of caffeine in the prevention of apnea in low birth weight children. Methods 90 cases of low birth weight children were evenly divided into two groups according to hospital number of odd and even. The control group was given aminophylline to prevent apnea, and the observation group was given caffeine to prevent apnea. The incidence of apnea and related indicators were observed after treat- ment. Results The incidence of apnea within postnatal 10 days was 42. 22%, and 48.89% 32-week gestational age before in the control group, which was 11.11% and 13.33% in the observation group, respectively （P 〈0. 05）. There were significant differences in oxygen time after treatment, time of weight increased to 2kg, duration of hospital stay, incidence of mechanical ventilation, scleroderma, sepsis, incidence of intracranial hemorrhage and other com- plications, β-endorphin level between the two groups （ P 〈 0. 05 ）. There was no significant difference in fasting blood glucose, potassium, blood pressure, and arterial carbon dioxide partial pressure of arterial oxygen saturation （P 〉 0. 05）. Conclusion The application of caffeine can effectively decrease the incidence of apnea in low birth weight children.

关 键 词：咖啡因 超低出生体重儿 呼吸暂停 疗效 

分 类 号：R722.1[医药卫生—儿科]