208例药品不良反应报告分析  

Analysis of 208 Adverse Drug Reaction Reports

作　　者：盛长城[1] 谢娟[1] 王清忱[1] 樊凌燕[1] 李莲华[1] 钱鑫[1] 左鼎[1] 熊世娟[1] 

机构地区：[1]贵州省人民医院药剂科,贵阳550002

出　　处：《药物流行病学杂志》2015年第8期488-492,共5页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:分析药品不良反应(ADR)的发生情况、发生特点及相关因素,为临床合理用药提供参考。方法:对2013年收集并上报的208例ADR,分别从性别与年龄、给药途径、因果关系评价、报告人职业分布、涉及的药品种类、累及的器官或系统及临床表现等方面进行统计、分析。结果:208例ADR报告中,40岁以上的中老年患者所占比例最大,占76.92%;女患者构成比略高,占51.44%;静脉滴注引起ADR为144例(69.23%);涉及的药品中,抗肿瘤药物、抗感染药物、心血管系统用药致ADR构成比高;ADR临床主要表现为皮肤及其附件损害(55例)、全身性损害(50例)、血小板和出血凝血障碍(46例)。结论:抗肿瘤药物、抗感染药物、心血管系统用药是ADR监测的重点药物,医药护要共同努力,加强特殊人群和重点药物的ADR监测,提高合理用药水平,减少药源性疾病的发生。Objective ：To analyze the occurrence, characteristics and related factors of ADR so as to provide refer- ences for clinical rational drug use. Methods：A total of 208 ADR reports collected in 2013 were analyzed statistically in re- spects of patients ＇ gender and age, route of administration, causality assessment, reporters ＇ occupation, drug types, ADR-involved organs or systems and clinical manifestations, etc. Results： Among 208 ADR cases, patients aged over 40 occupied a high proportion （76.92%）, and the constituent ratio of female （51.44%） was higher than that of male. Intra- venous infusion caused 144 cases of ADR （69.23%）. Most of the ADR were caused by antitumor drugs, anti-infective drugs and cardiovascular drugs. ADR mainly occurred in skin and appendages disorders （55 cases）, body as a whole-gen- eral disorders （50 cases） and platelet, bleeding ＆ clotting disorders （46 cases）. Conclusion：Doctors, pharmacists and nurses should strengthen the ADR monitoring for special group and major medicine such as antitumor drugs, anti-infective drugs and cardiovascular drugs to promote rational use of drug in the clinic and reduce the drug-induced disease.

关 键 词：药品不良反应 报告 回顾性分析 监测 药物警戒 

分 类 号：R951[医药卫生—药学]