干细胞治疗肝硬化的研究进展  

Liver stem cell therapy for cirrhosis: advances in cell classification and selection

作　　者：徐莹[1] 刘平[1] 慕永平[1] 

机构地区：[1]上海中医药大学附属曙光医院肝病研究所,上海201203

出　　处：《临床肝胆病杂志》2015年第8期1360-1364,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金面上项目(81173223;81273728)

摘　　要：近年来,伴随分子生物学和细胞生物工程技术的迅速发展,基于干细胞移植技术的肝脏重建已经成为急、慢性肝衰竭治疗研究的新热点。通过对不同种类干细胞在肝硬化治疗领域基础与临床研究的归纳,以及根据患者疾病状态的特异性对移植干细胞类型的最优选择进行了总结,大量的实验研究表明干细胞治疗肝硬化的技术正在逐渐成熟,在肝脏再生领域具有广阔的应用前景,其强大的治疗潜力会为终末期肝硬化患者带来希望。Liver cirrhosis is the final outcome of various chronic liver diseases. In recent years,along with the rapid development of molecular biology and cell biological engineering technology,liver regeneration based on stem cell transplantation technique has become a new research hotspot for treatment of acute and chronic hepatic failure. Here we review basic and clinical studies on different types of stem cells for the treatment of liver cirrhosis and optimal choices of the stem cell type used for transplantation based on specificity of patients＇ particular status. A large number of experimental studies reveal that the technology of stem cell for the treatment of liver cirrhosis has gradually become mature with a broad prospect of application in the field of liver regeneration. This technology that holds enormous potential for treatment will bring hopes to the patients with end- stage liver cirrhosis.

关 键 词：肝硬化 干细胞 治疗 综述 

分 类 号：R575.2[医药卫生—消化系统]