SUMO-1及ERα在子宫内膜癌中的表达及相关性研究  

Study on Expression and Correlation of SUMO-1 and ERα in Endometrial Carcinoma

作　　者：袁俐[1] 袁梦岚[1] 陈旭红[1] 姜忠敏[2] 李艳霞[3] 马晓芳[3] 刘晓智[3] 

机构地区：[1]天津市第五中心医院妇产科,300450 [2]天津市第五中心医院病理科,300450 [3]天津市第五中心医院中心实验室,300450

出　　处：《国际妇产科学杂志》2015年第4期470-472,I0003,共4页Journal of International Obstetrics and Gynecology

摘　　要：目的:检测小类泛素化修饰蛋白1(SUMO-1)及雌激素受体α(ERα)在子宫内膜癌中的表达情况及两者间的关系。方法:选取天津市第五中心医院2006年1月—2013年12月间收集的50例子宫内膜癌标本及35例正常子宫内膜标本,采用免疫组织化学方法检测SUMO-1蛋白和ERα蛋白在所有组织标本中的表达情况,免疫荧光化学方法检测两者在子宫内膜癌中的共定位情况,分析SUMO-1和ERα的表达与子宫内膜癌临床病理参数的关系。结果:SUMO-1蛋白在子宫内膜癌中的阳性表达率高于对照组,而ERα蛋白则相反,2组差异均有统计学意义(均P<0.05)。子宫内膜癌患者SUMO-1蛋白和ERα蛋白阳性表达率在不同年龄、不同绝经状态、不同组织学分级的患者中差异有统计学意义(均P<0.05),不同病理类型的患者2种蛋白的阳性表达率差异无统计学意义(P>0.05)。SUMO-1和ERα在子宫内膜癌中的表达具有较好的一致性(Kappa=0.875,Z=5.473,P=0.001)。结论:SUMO-1和ERα在子宫内膜癌中存在共表达关系,两者在子宫内膜癌发生和发展过程中可能发挥协同作用。Objective：To detect the expression level of small ubiquitin-like modifier protein-1（SUMO-1） and estrogen receptor alpha（ERα）, and their correlation in endometrial carcinoma. Methods：50 cases of endometrial carcinoma samples and35 cases of normal endometrial samples were collected in our hospital from 2006 January to 2013 December. The expression of SUMO-1 and ERα were detected in all tissues by immunohistochemical method, and their co-localization expression was detected by immunofluorescence method. Then the relationship between SUMO-1 and ERα, and their express level and the clinicopathological parameters were analyzed respectively. Results：The positive rates of SUMO-1 protein in endometrial carcinoma was higher than that in control group, while the expression of ERα protein was the opposite, and the difference between the two groups was statistically significant（P〈0.05）. The positive rate of SUMO-1 and ERα in endometrial carcinoma patients were differ in different ages, menopausal status and different histological grades（all P〈0.05）, but the difference was not significant in different pathology subtypes（P〉 0.05）. The expression of SUMO-1 and ERα protein had good consistency（Kappa=0.875, Z=5.473, P=0.001）. Conclusions：SUMO-1 and ERα were co-localization in endometrial carcinoma, and may play a synergistic role in the process and development of endometrial carcinoma.

关 键 词：癌 子宫内膜肿瘤 雌激素受体Α 类泛素化修饰蛋白 

分 类 号：R737.33[医药卫生—肿瘤]