小细胞肺癌的临床病理与预后  

The clinic - pathology and prognosis of small cell lung cancer

作　　者：刘复生[1] 孙燕[1] 殷蔚伯[1] 张汝刚[1] 果红[1] 温芃 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤研究所,北京100021

出　　处：《癌症进展》2003年第1期53-56,52,共5页Oncology Progress

摘　　要：本文报告随诊5年以上的小细胞肺癌164例,着重分析病理类型(WHO分型以及IASLC分型)治疗方式与预后的关系。其中15例采用免疫组化学方法,研究它的内分泌表达以及上皮性抗原的表达,3例作透射电镜观察。结果显示,小细胞癌的组织学类型与患者生存时间无肯定关系,在38例单纯手术或伴有放(化)等辅助治疗的5年存活率为21％(8/38),非手术治疗的123例5年存活率为7.3％(9/123),显示小细胞肺癌手术+放(化)疗能够提高患者5年存活率;在15例进行内分泌和上皮性抗原标记中,7例内分泌表达(S-100、NSE)阳性,12例上皮性抗原(CAM5.2)表达阳性,显示小细胞肺癌来自内胚层和内分泌细胞。To evaluate prognostic factors effecting survival, 164 cases of the small cell lung cancer involved histologi-cal type and treatment was analysed. The treatment consisted of surgery, chemotherapy, radiotherapy or surgery + chemo + radio therapy. The 5 year survival rates was 21% (8/38) in the surgery series. However in the 123 cases of nonsurgery group. The 5 year survival rates was 7.3% (9/123). This results was showing that the surgery associated with chemotherapy or radiotherapy could be improving the survival rates of the patients in the small cell lung cancer, In this investigation, 15 cases of small cell lung cancer was marked using monoclone antibody S - 100. NSE. and CAMS. 2. seven cases of endocrine showed positive and 12 cases of epithelial antigen (CAM5.2) showed positive. 3 cases of small cell lung cancer was observeted by electron microscopy. All of them was showing core neurosecretary granular. This investigation determined that the small cell lung cancer was from entoderm and endocrine cells.

关 键 词：小细胞肺癌 手术 预后 

分 类 号：R734.2[医药卫生—肿瘤]