阿立哌唑对青少年强迫症治疗的增效作用对照研究  

Control study of synergistic effects of fluvoxamine and aripiprazole on adolescent obsessive-compulsive disorder a randomized,controlled study

作　　者：雷彤[1] 孙凌[1] 李玄[1] 

机构地区：[1]天津市精神卫生中心,天津300222

出　　处：《天津药学》2015年第4期34-36,共3页Tianjin Pharmacy

摘　　要：目的:探讨阿立哌唑联合氟伏沙明对青少年强迫症的临床疗效和安全性。方法:将78例患者随机分为实验组和对照组各39例,两组均口服氟伏沙明治疗,实验组联合阿立哌唑,均为口服连续给药,氟伏沙明平均剂量(113.5±50.6)mg/d,阿立哌唑平均剂量(7.6±2.3)mg/d,观察12周,并于治疗前和治疗后4周末、8周末、12周末进行YaleBrown强迫量表评定临床疗效,TESS评定不良反应。结果:治疗4周末两组Yale-Brown强迫量表评分均较治疗前有显著下降,但实验组在8周末和12周末下降更为显著(P<0.01)。治疗12周末,实验组总有效率为83.3%,对照组为71.9%,实验组高于对照组,但两者无显著性差异。治疗4周末、8周末、12周末实验组和对照组TESS量表评分差异无显著性,两组不良反应均较轻微,实验组以神经系统不良反应为主,对照组以植物神经性系统反应为主。结论:阿立哌唑联合氟伏沙明能增强抗强迫效应,治疗青少年强迫症起效快,疗效显著,安全性高,依从性好,优于单用氟伏沙明治疗。Objective： To explore the efficacy and safety of fluvoxamine combined with aripiprazole in the treatment of adolescent obsessive- compulsive disorder（ OCD）. Methods： Seventy- eight OCD patients were randomly assigned into two groups,each of which contained 39 subjects. Patients in the treatment group received aripiprazole（ 7. 6 ± 2. 3） mg / d plus fluxamine（ 113. 5 ±50. 6） mg / d while patients in the controlled group only took fluxamine（ 113. 5 ± 50. 6） mg / d. Both groups were administerd with drugs for 12 weeks. Efficacies were assessed with the Yale- Brown Obsessive Compulsive Scale（ Y- BOCS） and adverse reactions with the Treatment Emergent Symptom Scale（ TESS） prior to the treatment and at the end of the 4th,8thand 12 thweeks. Results：For both groups,Y- BOCS score was lower at the end of the 4thweek than that before the treatment but no statistcal difference was found（ P 0. 05）. However,at the end of the 8thand 12 thweeks,Y- BOCS score for the teatment group were significantly lower than that for the controlled group（ P 0. 01）. At the end of the 12 thweek,overall response rate was higher in the treatment group than in the controlled group（ 83. 3% vs 71. 9%）,but there was no statistically significant difference. There was no significant difference in TESS score for both groups at the end of the 4th,8thand 12 thweeks. Adverse reactions in both groups were mild,mainly affecting nervous system in the treatment group and vegetative nervous system in the control group. Conclusion： Fluxamine combined with aripiprazole could reinforce anti- obsessive effect and has an advantage over single fluvoxamine in efficacy,safety and compliance.

关 键 词：青少年强迫症 阿立哌唑 氟伏沙明 YALE-BROWN强迫量表 副反应量表 

分 类 号：R749.99[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]