丹参酮增强化疗药物拮抗黑色素瘤效果的研究  

Tanshinone enhances effects of anti-melanoma induced by chemotheraphy drugs

作　　者：于泳[1] 张林林[2] 秦治刚[2] 武月婷[2] 谢凤洋 杨煜[3] 

机构地区：[1]吉林大学白求恩医学院,长春130021 [2]吉林大学公共卫生学院,长春130021 [3]吉林大学基础医学院医学生物实验中心,长春130021

出　　处：《中国免疫学杂志》2015年第8期1053-1055,1059,共4页Chinese Journal of Immunology

摘　　要：目的:研究中药制剂丹参酮(TA)和抗肿瘤药物的卡铂(CA)联合应用对黑色素细胞瘤的抑制作用。方法:建立肿瘤模型后,分为模型组、丹参酮组、卡铂组、丹参酮+卡铂组,同时设立正常鼠为空白组。不同组别的小鼠分别给予腹腔注射PBS、丹参酮、卡铂、丹参酮和卡铂,空白组小鼠不做任何处理。结果:丹参酮+卡铂组小鼠的肿瘤体积和肿瘤质量显著小于丹参酮组、卡铂组和模型组(P<0.05);卡铂组小鼠的肿瘤体积和肿瘤质量显著小于丹参组和模型组(P<0.05);丹参酮+卡铂组小鼠体重增加显著好于丹参酮组和卡铂组(P<0.05)。结论:丹参酮和卡铂联合用药可以产生更好地抑制B16黑色素瘤增殖的效果。Objective： To investigate the inhibitory effects produced by combination of carboplatin（ CA） and Tanshinone（ TA）on the growth of B16. Methods： After the mice were injected B16 subcutaneously in the right thigh,the mice were divided into four groups,PBS group,TA group,CA group,and TA ＋ CA group. Normal mice were set up as control. Mice of PBS group were injected 0. 2ml PBS intraperitoneally; mice of CA group were injected 0. 5 mg CA intraperitoneally for four consecutive days and followed by four days without administration until the mice were killed; mice of CA ＋ TA group were injected 0. 5 mg CA intraperitoneally for four consecutive days and followed by four days without administration,TA（ 0. 5 g / kg body weight） was administered to the mice through gastric injection every day until the mice were killed. Results： The tumor weight and volume of CA ＋ TA mice were significantly smaller than those of CA mice,TA mice and PBS mice（ P〈0. 05）; the tumor weight and volume of CA mice were significantly smaller than those of TA mice and PBS mice（ P〈0. 05）. The body weight grow of TA ＋ CA mice was more significant than that of TA mice and CA mice（ P〈0. 05）. Conclusion： Combination of carboplatin（ CA） and Tanshinone（ TA） will produce a better inhibitory effects on the growth of B16 cells.

关 键 词：黑色素瘤 联合用药 丹参酮 卡铂 抗肿瘤作用 细胞凋亡 

分 类 号：R73[医药卫生—肿瘤]