慢性肾脏病高磷血症研究进展  

Hyperphosphatemia in Chronic Kidney Disease( CKD)

作　　者：王菁[1] 张晓燕[2] 管又飞[1,2] 

机构地区：[1]北京大学医学部生理学与病理生理学系,心血管教育部重点实验室,北京100191 [2]深圳大学医学部生理学系,深圳518060

出　　处：《生理科学进展》2015年第4期241-244,共4页Progress in Physiological Sciences

基　　金：国家自然科学基金(81200511;810300032)资助课题

摘　　要：磷是生命组成的必需元素,参与了能量代谢、信号转导和蛋白合成等一系列重要的生命过程。肾脏在人体磷稳态的维持中具有重要的功能。慢性肾脏病(CKD)患者普遍伴随着磷代谢紊乱,长期的高磷血症引起继发性甲状旁腺功能亢进症(SHPT)、肾性骨营养不良(ROD)、心血管系统病变(CVD)以及促进肾病的进展,增加了患者的死亡率。近年来,高磷血症作为上述疾病发生的独立危险因素得到了越来越多的关注和研究,进一步提升了慢性肾脏病的治疗效果。Phosphorus plays important roles in a variety of biological processes such as energy metabolism,cell signaling,nuclenic acid synthesis and membrane function. A major role of the kidney is to maintain phosphorus homeostasis. It is not surprising that when renal function begins to decline in CKD patients,the homeostasis is disrupted and serum concentration of phosphorus begins to increase. Hyperphosphatemia leads to a series of complications including secondary hyperparathyroidism,renal osteodystrophy,cardiovascular diseases and progression of CKD,which contributing to the excess mortality of CKD. In recent years,as an independent risk factor of health damage,hyperphosphatemia has attracted more and more concerns. The progression of researches about hyperphosphatemia has promoted the clinical therapies of CKD.

关 键 词：高磷血症 慢性肾脏病 继发性甲状旁腺功能亢进症 肾性骨营养不良 心血管疾病 

分 类 号：R363[医药卫生—病理学]