1-(2,6-二异丙基苯基)-2-苯基-1H-咪唑的合成  

Synthesis of 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole

作　　者：周林波[1] 鲁萌萌[1] 邢磊[1] 陈国良[1] 

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《精细化工中间体》2015年第4期52-54,共3页Fine Chemical Intermediates

摘　　要：以2,6-二异丙基苯胺为原料,与苯甲酰氯成酰胺,再经三氯氧磷氯代,氨基乙醛缩二乙醇亲核取代后,在磷酸作用下环合得到1-(2,6-二异丙基苯基)-2-苯基-1H-咪唑,4步反应的总收率为47.7%。目标化合物结构经ESI-MS、1H NMR确证。The target compound 1-（2,6-diisopropylphenyl）-2-phenyl-lH-imidazole was prepared in overall yield of 47.69% starting from 2,6-diisopropyl aniline via acylation by benzoyl chloride, chlorination by phosphorus oxychloride, nucleophilie substitution by aminoacetaldehyde diethyl acetal, and cyclization by phosphate. The structure of target compound was characterized by ^1H NMR and ESI-MS.

关 键 词：1-(2 6-二异丙基苯基)-2-苯基-1H-咪唑 2 6-二异丙基苯胺 苯甲酰氯 

分 类 号：TQ252.3[化学工程—有机化工]