多配体聚糖结合蛋白在大肠癌组织中的表达及其对预后的影响  

Prognostic value of syndecan binding protein in colorectal carcinoma

作　　者：刘会平[1,2] 杨磊[1,2] 丁彦青[1,2] 赵震[1,2] 于倩[1,2] 

机构地区：[1]南方医科大学南方医院病理科,广东广州510515 [2]南方医科大学基础医学院病理学系//广东省分子肿瘤病理学重点实验室,广东广州510515

出　　处：《南方医科大学学报》2015年第7期1003-1007,共5页Journal of Southern Medical University

基　　金：国家自然科学基金(K1010125)~~

摘　　要：目的通过对109例结肠癌患者中多配体聚糖结合蛋白(SDCBP)表达的分析,探讨其临床意义及对患者预后的影响。方法免疫组织化学法检测109例有10年随访资料,诊断为原发性结直肠癌患者中SDCBP的表达,分析其表达与结直肠癌患者各临床因素之间的关系,生存分析采用Kaplan-Meier和Cox回归分析法。结果 SDCBP的表达对结直肠肠癌患者的淋巴结转移、TNM分期及术后的生存期均有显著影响(P=0.001)、(P=0.033)、(P=0.004),但与患者的年龄,性别,肿瘤浸润深度,组织分化以及病理类型没有关系。Kaplan-Meier法检验,结果显示,109例结直肠癌患者中SDCBP高低表达组患者术后平均生存期及7年累计生存率分别为:52.300±6.508(月)、86.184±5.358(月);38.6±6.4(%)、61.5±6.7(%),整体水平及各组间水平的差异经Log-rank法分析均有统计学意义(χ2=10.585,P=0.001);Cox回归分析法发现:SDCBP的高表达和发生淋巴结转移是患者死亡的主要影响因素(B=0.605,P=0.034;B=0.677,P=0.013)。结论 SDCBP可作为提示大肠癌淋巴结转移、TNM分期及预后的一项指标。Objective To analyze the clinical significance of syndecan binding protein （SDCBP） expression in human colorectal carcinoma （CRC） and its value in predicting the postoperative survival of the patients. Methods The follow-up data for 10 years were collected from 109 primary CRC patients with immunohistochemical data of SDCBP expression in the tumor tissues. The relationship between SDCBP expression and the clinical factors was analyzed, and survival analysis was performed using the Kaplan-Meier and Cox regression analysis models. Results SDCBP expression in CRC was significantly associated with the postoperative survival time （χ2=8.336, P=0.004） and lymph node metastasis （P=0.001） of the patients, but not with age, gender, depth of invasion, tissue differentiation or histological type of the tumor. Kaplan-Meier survival curves showed that the patients expression high levels of SDCBP in the CRC tissues had a significantly shorter postoperative mean survival time and a lower 7-year survival rate than those with low SDCBP expressions [52.300 ± 6.508 vs 86.184 ± 5.358 months, （38.6±6.4）%vs （61.5±6.7）%;χ2=10.585, P=0.001]. Multivariate Cox analysis revealed that a high expression of SDCBP （B=0.605, P=0.034） and lymph node metastasis （B=0.677, P=0.013） were the main factors related to death in CRC patients. Conclusion SDCBP expression level can serve as an indicator for lymph node metastasis, TNM staging, and outcome prediction of CRC.

关 键 词：免疫组织化学 大肠癌 预后 

分 类 号：R735.34[医药卫生—肿瘤]