氟西汀联合小剂量奥氮平治疗重度抑郁症的临床疗效评价  

Evaluation Clinical Curative Effect of Fluoxetine Combine With Small Dose of Olanzapine in Treatment of Major Depressive Disorder

作　　者：刘锡亮[1] 曲春晖[1] 姜丽丽[1] 

机构地区：[1]山东省青岛市精神卫生中心老年二病房,266000

出　　处：《中国继续医学教育》2015年第23期147-148,共2页China Continuing Medical Education

摘　　要：目的 探讨氟西汀联合小剂量奥氮平治疗重度抑郁症的临床效果.方法 研究我院2013年6月-2015年4月收治的99例重度抑郁症患者的临床资料,根据治疗方法分为单一组（n=49）、联合组（n=50）.单一组给予氟西汀治疗,联合组在对照组治疗的基础上,联合服用小剂量奥氮平治疗,观察比较两组患者的临床治疗效果及不良反应.结果 联合临床治疗总有效率为96.0%高于单一组的75.5%,P〈0.05,差异具有统计学意义.联合组不良反应发生率为8.0%,单一组不良反应发生率为10.2%,P〉0.05,差异不具有统计学意义.结论 对重度抑郁症患者实施氟西汀联合小剂量奥氮平治疗,可以改善抑郁症状,减少不良反应发生,提高生存质量,是一种较为理想的临床治疗方法.Objective Analysis fluoxetine in combine with small dose of olanzapine in the treatment of major depressive disorder.Methods Selected 99 cases with major depression from June 2013 to April 2015 in our hospital, according to the treatment were divided into the single group （ n=49 ） and the joint group （ n=50 ）. Single group was treated with lfuoxetine, combined treatment group patients in the control group, on the basis of combining the small dose of olanzapine treatment, observed the clinical therapeutic effect of two groups were compared and the adverse reactions.Results The joint group the total effective rate was 96.0% higher than the single group 75.5%,P〈0.05, had difference statistically signiifcance. The joint group incidence of adverse reactions was 8.0%, the single group the incidence of adverse reactions was 10.2%,P〉0.05, had no difference statistically signiifcance.Conclusion The implementation of lfuoxetine in patients with major depressive disorder in combination with small dose of olanzapine can improve depressive symptoms, reduce the adverse reaction, improve the quality of survival, is a kind of ideal clinical treatment.

关 键 词：重度抑郁症 氟西汀 小剂量 奥氮平 

分 类 号：R749.41[医药卫生—神经病学与精神病学]