Lp-PLA2与缺血性脑血管病患者脑动脉狭窄的关系  

The relationship between the Lipoprotein-associated phospholipase A2 and cerebral artery stenosis in patients with ischemic cerebrovascular disease

作　　者：石艳超[1] 杜大勇[1] 许航[1] 李元培[1] 孟虹媛[1] 王江川[1] 张东菊[1] 

机构地区：[1]天津港口医院神经内科,天津300456

出　　处：《中风与神经疾病杂志》2015年第8期699-701,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨缺血性脑血管病患者脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2,LpPLA2)与脑动脉狭窄的相互关系。方法应用荷兰飞利浦公司生产的FD-20 C型臂血管造影系统,对355例缺血性脑血管病患者进行全脑血管造影及血浆Lp-PLA2检测,Lp-PLA2正常组患者(对照组)151例与Lp-PLA2升高组(病例组)204例患者的全脑血管造影结果进行比较。结果对照组与病例组脑动脉狭窄程度差异有统计学意义(χ2=15.69,P<0.05);随着Lp-PLA2的升高,脑动脉狭窄程度逐渐加重。结论 Lp-PLA2是缺血性脑血管病脑动脉狭窄的一种危险因素,脑血管狭窄与Lp-PLA2升高有关,Lp-PLA2在一定程度上反应脑血管狭窄程度。Objective To explore the relationship between lipoprotein-associated phospholipase A2（ Lp-PLA2） and cerebral artery stenosis of ischemic cerebrovascular patients. Methods Did cerebral angiography with FD-20 C-arm angiography system which produced by the Dutch company Philips and detected plasma of Lp-PLA2 among 355 patients who with ischemic cerebrovascular disease,compared cerebral angiography results between Lp-PLA2 normal group（ control group）and Lp-PLA2 increased group（ case group）. Results The cerebral artery stenosis between the control group and case group were statistically significant differences（ χ2= 15. 69,P〈0. 05）,along with the much increasing of Lp-PLA2,the more severe of cerebral artery stenosis. Conclusion Lp-PLA2 may be a risk factor of cerebral artery stenosis in ischemic cerebrovascular disease,cerebral vascular stenosis is related with Lp-PLA2,which can reflect the severity of cerebral artery stenosis to some extent.

关 键 词：脑缺血 脂蛋白相关磷脂酶A2 脑动脉狭窄 

分 类 号：R743.3[医药卫生—神经病学与精神病学]