DNA甲基化与健康长寿的研究进展  

Advance in relationship between DNA methylation and healthy ageing and longevity

作　　者：孙亮[1,2] 杨泽[1,2] 

机构地区：[1]北京老年医学研究所卫生部老年医学重点试验室 [2]北京医院,100730

出　　处：《中国老年保健医学》2015年第4期14-17,共4页Chinese Journal of Geriatric Care

基　　金：北京市科技新星计划(Z121107002512058);国家自然科学基金(30972709;81061120527;81241082;81370445);卫生部公益性研究基金(201302008);国家科技部十二五支撑计划项目(2012BAI10B01)

摘　　要：表观遗传修饰在基因调控的过程中起重要作用,抑制疾病发生的相关基因在健康长寿的个体中可能也受到表观遗传修饰,从而参与促进健康长寿的表型。年龄相关的DNA甲基化改变,涉及到老年个体中的代谢性疾病、心血管疾病、肿瘤等增龄性疾病的发生与发展。关于长寿和延缓衰老的作用目前基于基因变异领域得到支持性的证据有限,但近年来DNA甲基化的增龄性变化模式已经得到多个人群证实贯穿于生命全程而存在,其改变受到性别和年龄阶段影响,这将是我们认识生命发生发展的重要科学突破口。但是对于DNA甲基化的发生原因和确切机制还需要未来进一步研究,未来对于认识衰老、延缓衰老,以及个体化"精准"监测衰老进程和干预疗效,将提供更为广阔的前景。Epigenetic modifications play an important role in the process of gene regulation. And inhibition of disease genes in longevity and health of individuals may have also been associated with epigenetic modifications,contributing to the phenotype of longevity and healthy. Age-related DNA methylation is involved in metabolic disease,cardiovascular disease,and cancer in elderly. The evidence is limited about genetic variations in longevity and anti-aging effect,but in recent years,the role of DNA methylation changes in human has been reported extensively throughout the entire life,which is affected by gender and age,this will be helpful to understand the nature of life. Although the reason for cause of DNA methylation and the exact mechanism still needs further research,it is still promisingto understand aging,anti-aging,and individualized ＂accurate＂monitoring of effect of intervention.

关 键 词：健康长寿 衰老 DNA甲基化 表观遗传 个体化 

分 类 号：R363[医药卫生—病理学]