自拟复方中药联合化疗对晚期结直肠癌疗效观察  

Self-made Compound Chinese Medicine Combined with Chemotherapy for the Treatment of Advanced Colorectal Cancer

作　　者：刘桂伟[1] 马小群[1] 任维聃[1] 王雪松[1] 王明[1] 李泽钊[1] 姜国胜[1] 

机构地区：[1]沧州市中心医院,河北沧州061001

出　　处：《辽宁中医药大学学报》2015年第9期117-119,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：沧州市科学技术研究与发展指导计划项目(131302183)

摘　　要：目的:观察自拟复方中药联合FOLFOX4化疗方案治疗晚期结直肠癌的疗效及毒副反应。方法:选择晚期结直肠癌术后化疗患者40例,随机分为治疗组20例,采用自拟复方中药联合FOLFOX4方案联合治疗,对照组20例,单纯采用FOLFOX4方案化疗。比较两组化疗前后生存质量改善、毒副反应程度、临床常见症状改善、体力状况及血清肿瘤标记物(CEA、CA199、CA724)、肿瘤坏死因子-α(TNF-α)及白介素-12(IL-12)含量以及血常规、肝肾功及心电图等相关检查指标的变化情况。结果:治疗组在降低血清肿瘤标记物CEA、CA199,减轻化疗过程中白细胞减少、贫血、恶心呕吐,改善临床症状等方面均优于对照组,治疗组可明显改善患者生存质量,优于对照组。TNF-α及IL-12治疗组化疗后升高(P<0.05),对照组降低(P<0.05)。结论:自拟复方中药联合FOLFOX4方案对化疗毒副反应具有一定的防治作用,并能降低血清肿瘤标记物水平,同时可以改善患者临床症状和机体一般状况。Objective：To observe the effect and toxicity of the regimen of self-made compound Chinese medicine combined with chemotherapy scheme of FOLFOX4 for the treatment of advanced colorectal cancer. Methods：Forty advanced colorectal cancer patients after doing colorectal operation were selected and divided into two groups randomly. The twenty patients in the treat group were treated with Self-made compound Chinese medicine combined with FOLFOX4 chemical therapy and the twenty patients in the control group were treated simply with FOLFOX4 chemical therapy. The seriousness of the adverse effects during the chemical therapy,alleviation of clinical symptoms,improvement of common conditions and changes of serum tumor indicating（CEA,CA199,CA724）,tumor necrosis factor alpha（TNF-α）and interleukin 12（IL-12）content,the target of liver and kidney function,blood routine,ECG,were compared and the differences were analysed by statistics. Results：The serum level of CEA,CAl99,alleviating symptoms,improving common conditions and reducing adverse effects（1eucopenia,anemia,nausea and vomit）of chemical therapy in the treat group and control group all had significant difference.The treatment group can obviously improve the quality of survival,is better than the control group. Levels of TNF-α and IL-12 significantly elevated in the test group after treatment but lowered in the control group,showing significant difference between groups（both P〈0.05）. Conclusion：Self-made compound Chinese medicine combined with FOLFOX4 chemical therapy has remarkable therapeutic effect oil reducing adverse effects,it can reduce serum tumor indicating,and it can improve clinical symptoms and common conditions.

关 键 词：结直肠癌 临床研究 中医药疗法 

分 类 号：R735.3[医药卫生—肿瘤]