补血养心抗癌汤联合CAF方案化疗对乳腺癌患者外周血癌胚抗原、血清糖蛋白抗原153影响以及改善化疗药物所致心脏毒性研究  

Buxue Yangxin Kangai Decoction Combined with CAF Chemotherapy for Breast Cancer Patients Thc Peripheral Blood's CEA,CA153 Impacts and Improve Chemotherapy-induced Cardiotoxicity

作　　者：林冠宏[1] 张军 

机构地区：[1]辽宁省肿瘤医院 [2]辽宁省盖州市65535部队医院

出　　处：《辽宁中医药大学学报》2015年第9期171-173,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:探析补血养心抗癌汤联合CAF方案化疗对乳腺癌患者外周血癌胚抗原、血清糖蛋白抗原153影响,以及改善化疗药物所致心脏毒性的研究。方法:应用随机平行对照方法,将108例住院患者按随机数字表法,随机分为两组。对照组54例应用CAF方案化疗,治疗组54例患者应用补血养心汤100 m L,日3次口服;化疗用法、用量同对照组,治疗21 d为1周期。行6周期化疗后观察中医症状改善情况、卡式评分、肿瘤标志物癌胚抗原(CEA)、血清糖蛋白抗原153(CA153)水平,心电图改善,血清肌钙蛋白(c Tn T)、肌酸激酶(CK)及乳酸脱氢酶(LDH)含量的变化,骨髓抑制情况。结果:治疗组第4、第6周期症状评分明显降低,与治疗前比较差异均有统计学意义(P<0.01),对照组第4、6周期症状评分升高明显,与治疗前及治疗组同期相比差异均有统计学意义(P<0.01);治疗后,治疗组改善率为55.56%,对照组改善率为35.18%。两组患者生活质量改善率比较有显著性差异(P<0.05);治疗后两组CEA、CA153与治疗前相比均显著降低(P<0.01),且治疗组降低程度优于对照组(P<0.01);治疗组治疗后异常心电图发生率7.41%低于对照组29.62%,差异有统计学意义(P<0.01),治疗后治疗组c Tn T、CK及LDH含量较治疗前均降低(P<0.01),且低于对照组(P<0.01);治疗后,两组患者血红蛋白、白细胞及血小板计数与治疗前相比均降低(P<0.01),且治疗组降低幅度低于对照组(P<0.01)。结论:补血养心汤联合化疗能改善患者化疗期间出现的临床症状,提高生活质量,减轻心脏毒性,抑制病情进展,临床疗效可靠。Objective：Buxue Yangxin Kangai Decoction combined with CAF chemotherapy for breast cancer patients Thc peripheral blood＇s CEA,CA153 impacts and improve chemotherapy-induced cardiotoxicity. Method：Randomized parallel-group method,108 cases of hospitalized patients were randomly divided randomly into two groups. The control group of 54 patients were treated with CAF chemotherapy,the treatment group of 54 patients with heart blood nourishing soup application 100 ml,three times a day orally;use of chemotherapy,the same amount in the control group,21 d for a cycle. After six cycles of chemotherapy,the patient＇s clinical symptoms improve the situation,change card score,CEA,CA153 levels,ECG improvement,c Tn T,CK and LDH levels,and the case of bone marrow suppression. Results：Treatment group 4,6 cycles symptom score was significantly reduced. Significant differences（P〈0.01）compared with that before treatment,the control group 4,6 cycle symptom scores increased significantly,with significant differences before treatment,compared with the same period in the efficacy of the treatment group difference was significantly（P〈0.01）;After treatment,the treatment group improved rate of 55.56%,improvement in the control group was 35.18%. There are two groups to improve the quality of life in patients with significant differences（P〈0.05）;After treatment,the CEA,CA153,compared with before treatment were significantly lower（P〈0.01）,the magnitude of the treatment group compared with the control group decreased significantly（P〈0.01）;After treatment,the incidence of abnormal ECG was 7.41%,the incidence of 29.62% in the control group,the difference was statistically significant（P〈0.01）,the treatment group c Tn T,CK and LDH levels are lower than that before treatment（P〈0.01）,and lower than in the control group（P〈0.01）;After treatment,the two groups of patients with hemoglobin,white blood cell and platelet counts were lower（P〈0.01）compared to before the treatment,and the treatme

关 键 词：补血养心抗癌汤 乳腺癌 癌胚抗原 血清糖蛋白抗原 心脏毒性 

分 类 号：R737.9[医药卫生—肿瘤]