手性缩醛的催化不对称合成研究进展  

Catalytic Asymmetric Synthesis of Chiral Acetals

作　　者：杜鹏[1] 周海峰[1] 沈冠硕[1] 邹坤[1] 

机构地区：[1]三峡大学生物与制药学院天然产物研究与利用湖北省重点实验室,宜昌443002

出　　处：《有机化学》2015年第8期1641-1649,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学青年基金(No.21202092);三峡大学人才科研启动基金(No.KJ2012B080)资助项目~~

摘　　要：缩醛是许多药物和天然产物分子中常见的结构单元,研究发现手性缩醛的生物活性通常优于其消旋体.由于手性缩醛存在消旋化倾向,其催化不对称合成具有挑战性,近年来才引起关注.综述了目前手性N,N-缩醛、N,O-缩醛、N,S-缩醛、O,O-缩醛的催化不对称合成研究进展,及其在含缩醛骨架手性药物合成中的应用.Acetals are common building blocks of many drugs and natural product molecules. It was found that the biological activity of chiral acetals is usually superior to their racemates. The catalytic asymmetric synthesis of chiral acetals is challenge for its racemization and attracts attention until recent years. In this review, the recent studies on catalytic asymmetric synthesis of chiral aminals, N,O-acetals, N,S-acetals, O,O-acetals, as well as its application in synthesis of chiral drugs containing acetal moieties are reviewed.

关 键 词：手性缩醛 催化不对称合成 手性磷酸 

分 类 号：O621.3[理学—有机化学]