趋化因子CXCL12对调控胃癌生物学作用的机制研究进展  

Regulating mechanism of chemokine of CXCL12 on the progress of gastric cancer

作　　者：王路兵[1] 姜波健[2] 

机构地区：[1]上海交通大学医学院附属新华医院崇明分院普外科,上海202150 [2]上海交通大学医学院附属第三人民医院普外科,上海201900

出　　处：《国际外科学杂志》2015年第7期501-504,共4页International Journal of Surgery

基　　金：上海市崇明县卫生局科课题基金（No.CW2013-08）

摘　　要：CXCL12及其受体CXCR4和CXCR7的表达与癌症,尤其是胃癌的发展密切相关,在癌症的生长增生、肿瘤侵袭和转移中通过多种信号通路发挥作用.本文检索CXCL12、信号通路和癌症,就趋化因子CXCL12在癌症,尤其是胃癌中的作用及其调控机制作一综述.The chemokine CXCL12 and its receptor CXCR4 played a very important role in the gastric carcinoma,which promoted the growth,invasion,and metastasis of the gastric carcinoma through various of signal pathways.In this paper,the literatures related CXCL12,signal pathways and gastric carcinoma were retrieved and explored.And the authors present the research progress concerning the roles of CXCL12 and its regulating mechanism in neoplasm,especially in gastric cancer.

关 键 词：胃肿瘤 趋化因子类 信号通路 

分 类 号：R730.3[医药卫生—肿瘤]