盐酸法舒地尔对高血压脑出血患者血肿周围组织血流量的影响研究  

Impact of Fasudil Hydrochloride on Blood Flow of Hematoma around Tissue in Patients with Hypertensive Cerebral Hemorrhage

作　　者：孙文艳[1] 罗利俊[1] 

机构地区：[1]湖北省武汉市第一医院神经内科,430030

出　　处：《实用心脑肺血管病杂志》2015年第7期19-22,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：武汉市科学技术局项目(wh201405014)

摘　　要：目的探讨盐酸法舒地尔对高血压脑出血患者血肿周围组织血流量的影响。方法选择2013年12月—2014年12月在武汉市第一医院就诊的高血压脑出血患者80例,随机分为观察组和对照组,各40例。对照组患者给予常规治疗,观察组患者在常规治疗基础上给予盐酸法舒地尔治疗。比较两组患者治疗前和治疗后15 d局部脑血流量(r CBF),治疗前、治疗后7 d及治疗后15 d血肿体积及血肿周围低密度区体积,治疗前、治疗后7 d、治疗后15 d及治疗后85 d美国国立卫生研究院卒中量表(NIHSS)评分,治疗前、治疗后15 d及治疗后85 d改良Rankin量表(mRS)评分。结果两组患者治疗前后中心区、额顶叶区及治疗前周边近区、周边远区r CBF比较,差异无统计学意义(P>0.05);治疗后观察组患者周边近区和周边远区r CBF大于对照组(P<0.01)。两组患者治疗前血肿体积和治疗前、治疗后7 d血肿周围低密度区体积比较,差异无统计学意义(P>0.05);观察组患者治疗后7 d、治疗后15 d血肿体积及治疗后15 d血肿周围低密度区体积均小于对照组(P<0.01)。两组患者治疗前、治疗后7 d NIHSS评分及治疗前、治疗后15 d mRS评分比较,差异无统计学意义(P>0.05);观察组患者治疗后15 d、治疗后85 d NIHSS评分及治疗后85 d mRS评分均低于对照组(P<0.01)。结论盐酸法舒地尔能有效增加高血压脑出血患者血肿周围组织血流量,促进神经功能恢复。Objective To investigate the impact of fasudil hydrochloride on blood flow of hematoma around tissue in patients with hypertensive cerebral hemorrhage. Methods A total of 80 patients with hypertensive cerebral hemorrhage were selected in the First Hospital of Wuhan from December 2013 to December 2014,and they were randomly divided into observation group and control group, each of 40 cases. Patients of control group were given conventional treatment, while patients of observation group were given extra fasudil hydrochloride based on fasudil hydrochloride. Regional cerebral blood flow（ r CBF）before treatment and after 15 days of treatment, hematoma volume and hematoma around low-density area volume before treatment and after 7,15 days of treatment,National Institute of Health Stroke Scale（ NIHSS） score before treatment and after7,15,85 days of treatment,modified Rankin scale（ mRS） score before treatment and after 15,85 days of treatment were compared between the two groups. Results No statistically significant differences of r CBF of central region or frontal-parietal region was found between the two groups before or after treatment（ P〈0. 05）. No statistically significant differences of r CBF of peripheral near region or peripheral distant region was found between the two groups before treatment（ P〈0. 05）,while r CBF of peripheral near region and peripheral distant region of observation group were lager than those of control group after treatment（ P〈0. 05）. No statistically significant differences of hematoma volume or hematoma around low-density area volume was found between the two groups before treatment,nor was hematoma around low-density area volume after 7 days of treatment（ P〈0. 05）; hematoma volume of observation group was statistically significantly smaller than that of control group after 7,15 days of treatment,respectively,so was hematoma around low-density area volume after 15 days of treatment（ P〈0. 01）. No statistically significant differences of NIHSS score w

关 键 词：颅内出血 高血压性 盐酸法舒地尔 血肿 血流量 

分 类 号：R743.34[医药卫生—神经病学与精神病学]