TLR9介导的炎症反应与蛛网膜下腔出血后脑血管痉挛关系的研究进展  

Research Progress of TLR9 Mediated Inflammation in the Cerebral Vasospasm after Subarachnoid Hemorrhage

作　　者：王那仁朝格吐 李思慧[3] 武彦[4] 

机构地区：[1]通辽市医院医患办,内蒙古通辽028000 [2]内蒙古医科大学,呼和浩特010059 [3]通辽市医院神经外科,内蒙古通辽028000 [4]内蒙古医科大学附属医院病理科,呼和浩特010059

出　　处：《医学综述》2015年第17期3108-3110,共3页Medical Recapitulate

摘　　要：蛛网膜下腔出血(SAH)是脑血管破裂,血液流至蛛网膜下腔出现的一组症状,是一种高发病率、高病死率的脑血管疾病。脑血管痉挛(CVS)是SAH一个潜在的致命性并发症。新近研究表明,Toll样受体9(TLR9)作为TLRs家族的重要成员,通过与特异性的配体相结合,激活先天免疫系统,参与CVS和脑缺血引发的炎症反应。该文就TLR9介导的炎症反应与SAH后CVS关系的研究进展作一综述,以期为临床治疗措施提供有意义的理论依据。Subarachnoid hemorrhage（SAH） is serious vascular disease with high mortality and morbidity, the clinical manifestations of which are cerebral vascular rupture, blood flowing to the subarachnoid. Cerebral vasospasm（CVS） is a potentially fatal complication of SAH. Recent studies showed that Toll-like receptor 9 （TLRg） is an important member of TLRs family, which combines with specific ligands and activates the innate immune system,thusqnvolved in the inflammation caused by CVS and cerebral ischemia. Here is to make a review of the research progress of TLR9 mediated inflammation in CVS after SAH,in order to provide a theoretical guidance for the clinical intervention measures.

关 键 词：蛛网膜下腔出血 脑血管痉挛 炎症反应 TOLL样受体9 

分 类 号：R743.35[医药卫生—神经病学与精神病学]