CD44v6在腺样囊性癌的表达及临床意义  

Expression and its clinical significance of CD44v6 in adenoid cystic carcinoma

作　　者：李雷激[1] 向兰[1] 覃纲[1] 张迪[2] 刘跃华[1] 祝琳[1] 

机构地区：[1]泸州医学院附属医院耳鼻咽喉头颈外科,四川泸州646000 [2]眉山市人民医院耳鼻咽喉科,四川眉山620000

出　　处：《中国耳鼻咽喉颅底外科杂志》2015年第4期280-283,共4页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：四川省卫生厅立项课题(07107)

摘　　要：目的通过对60例腺样囊性癌(adenoid cystic carcinoma,ACC)及20例癌旁正常组织中CD44v6表达情况的检测,探讨其表达与ACC发生发展及嗜神经侵袭转移等临床病理特征间的关系。方法回顾性分析60例ACC患者的临床资料及收集ACC组织石蜡标本。采用免疫组化Envision法检测CD44v6在各标本中的表达情况,结合患者临床资料,分析它们的表达与ACC患者临床病理参数间的关系。结果 CD44v6的表达在ACC癌细胞的胞浆及胞膜中为强阳性,其表达与ACC的临床分型、T分级、复发、转移及神经周围侵袭有关(t值分别为3.525,3.387,3.617,2.124,2.064;P值分别为0.011,0.010,0.044,0.038,0.044)。结论 CD44v6在ACC与肿瘤恶性程度、T分级、有无神经周围侵袭、复发、转移呈正相关关系,两种分子的异常高表达可能提示其在ACC发生发展及恶化过程中起促进作用。Objective To explore the expression of CIM4v6 in adenoid cystic carcinoma （ACC） , and to discuss the relationship between the expression and clinicopathological characteristics （including development and neurotropic invasion and metastasis） of this tumor. Methods Clinical data of 60 patients with ACC were analyzed retrospectively and their paraffin embedded sections were collected. 20 specimens of adjacent normal tissues were chosen as control. Immunohistochemical envision method was used for detecting the expression of CD44v6 in all specimens. The relationship between the expression of CD44v6 and elinicopathologieal characteristics of ACC was analyzed. Results CD44v6 was intensively expressed in cell membrane and cytoplasm of ACC. The expression intensity was correlated to clinical type, T stage, per/neural invasion （ PNI）, recurrence and metastasis of the tumor （ all P 〈 0.05）. Conclusion Expression of CD44v6 is positively related with the malignancy, T stage, PNI, recurrence and metastasis of ACC. Abnormal high expression of CD44v6 may prompt occurrence, development and deterioration of ACC.

关 键 词：腺样囊性癌 嗜神经侵袭 信息分子 免疫组织化学 

分 类 号：TQ786[化学工程] R739.65[医药卫生—肿瘤]