银杏黄酮对恶性卵巢肿瘤化疗所致功能损伤的保护作用机制  

The protection and mechanisms of Ginkgetin for function impairment of chemotherapy-induced malignant ovarian tumors

作　　者：李娜[1] 常征[1] 乔宗旭[1] 赵贵芬[1] 张丽娟[2] 

机构地区：[1]邢台市人民医院产科,河北邢台054000 [2]河北医科大学第二医院妇产科,河北石家庄050000

出　　处：《西部医学》2015年第9期1306-1308,共3页Medical Journal of West China

基　　金：国家自然科学基金(30940078

摘　　要：目的探讨银杏黄酮对恶性卵巢肿瘤化疗所致功能损伤的保护作用机制。方法将160例恶性卵巢肿瘤患者随机分为对照组与银杏黄酮组各80例,对照组患者行常规化疗,银杏黄酮组患者在常规化疗基础上予银杏黄酮治疗,观察两组患者化疗后的月经紊乱情况,检测并比较化疗前及化疗1、3和5个疗程后患者血清中的超氧化物歧化酶(SOD)、促卵泡生成素(FSH)和雌二醇(E2)水平。结果化疗第3和5个疗程后对照组月经紊乱率(31.3%和52.5%)显著高于银杏黄酮组(20.0%和37.5%,P<0.05);化疗前对照组的FSH和E2[(58.81±4.89)、(62.28±6.81)]与银杏黄酮组[(59.21±5.01)、(63.11±5.99)]差异无显著性(P>0.05);化疗1、3和5个疗程后对照组的SOD、FSH和E2[(50.27±10.23)、(64.17±4.80)、(58.01±6.19),(47.39±8.22)、(68.01±5.01)、(52.04±5.54),(42.44±7.13)、(72.33±5.89)、(45.82±5.09)]与银杏黄酮组的SOD、FSH和E2[(55.83±11.27)、(60.16±4.77)、(62.01±6.61),(56.57±9.01)、(64.22±5.41)、(57.00±5.81),(54.37±12.05)、(69.82±6.03)、(50.22±4.99)]水平比较,差异均有显著性(均P<0.05)。结论化疗对恶性卵巢肿瘤患者的卵巢功能有损伤,银杏黄酮对化疗所致卵巢功能损伤的保护作用机制可能是升高机体内SOD水平,起到抗氧化清除自由基的作用。Objective To investigate The protection and mechanisms of Ginkgetin for function impairment of chemotherapy-induced malignant ovarian tumors. Methods 80 patients in the control group with conventional chemotherapy treatment and 80 patients in Ginkgetin group with chemotherapy on the basis of given ginkgo flavonoids were involved in the present study. The superoxide dismutase （SOD）, follicle stimulating hormone （FSH） and estradiot （E2） were observed. Results After 3 and 5 courses of chemotherapy, The rate of menstrual disorders of control group （31.3% and 52.5 %） was significantly higher than that of Ginkgetin group （20.0 % and 37.5 %）, P〈0.05. There were no significant differences of FSH and E2 between the two groups before chemotherapy ,P〈0.05. After 3 and 5 courses of chemotherapy, the SOD, FSH and E2 of control group were significant different from that of Ginkgetin group,P〈0.05. After 1, 3, and 5 course of chemotherapy, SOD, FSH and E2 of the control group of SOD, FSH and E2 were different form that of ginkgo biloba extract group （P〈0. 05）. Conclusion Ginkgetin has protective effect for chemotherapy-induced ovarian dysfunction and the mechanism may be elevated body SOD levels.

关 键 词：银杏黄酮 恶性卵巢肿瘤 超氧化物歧化酶 

分 类 号：R737.31[医药卫生—肿瘤]