伽玛刀治疗伴脑转移非小细胞肺癌患者生存分析  

Survival and prognostic factors analysis of non-small cell lung cancer patients with brain metastases through gamma knife treatment

作　　者：康文星[1] 党亚正[1] 黄世高[1] 高红祥 

机构地区：[1]中国人民解放军第323医院放疗中心,陕西西安710054

出　　处：《西部医学》2015年第9期1321-1324,共4页Medical Journal of West China

基　　金：陕西省自然科学基金(CWS105B07)

摘　　要：目的探讨伽玛刀治疗伴脑转移瘤的非小细胞肺癌患者生存及预后的影响因素。方法对52例非小细胞肺癌伴脑转移瘤患者均行肺部原发灶及脑部转移灶伽玛刀姑息性放射治疗,其中头部治疗联合全脑放疗(WBRT)者13例。分别对年龄、病理、KPS评分、中枢外转移、全身化疗、联合全脑放疗进行单因素及多因素分析。结果全组中位生存期7个月,6个月和1、2年生存率分别为56%、25%和4%。单因素及COX模型多因素分析显示,年龄、KPS评分、中枢外转移、全身化疗均为影响预后的独立因素(P0.037、0.007、0.002和0.027,均P<0.05)。结论影响伴脑转移瘤非小细胞肺癌患者预后的因素主要与年龄、KPS评分、中枢外转移和全身化疗相关。Objective To analyze the survival and prognostic factors of patients with brain metastases of non-small cell lung cancer with gamma knife treatment. Methods We retrospectively analyze 52 patients with non-small cell lung cancer with brain metastases. The patients were completed by gamma knife palliative radiotherapy, including 13 cases treated by whole brain radiotherapy （WBRT）. The age, pathology, KPS score, central transfer, systemic chemotherapy, combined whole brain radiotherapy respectively were analyzed by single factor and multiple factors COX model. Resuits The median survival of 7 months and 6 months, 1 year, 2 year survival rates were 56 %, 25 % and 4 %, respectively. Single factor and multi-factors COX model analysis showed that age, KPS score, central transfer, systemic chemotherapy were independent factors affecting the prognosis. P values were 0. 037, 0. 007, 0. 002, 0. 027, respectively. Conclusion The patients with brain metastases in non-small cell lung cancer with influence factors of prognosis were age, KPS score, central transfer and systemic chemotherapy.

关 键 词：肺癌 脑转移瘤 伽玛刀 生存 

分 类 号：R734.2[医药卫生—肿瘤]