甲硝唑联合地塞米松预防根管治疗期间急症的临床疗效  

Metronidazole combined with dexamethasone for the prevention of endodontie interappointment emergencies

作　　者：王韬淑 唐镭[1] 

机构地区：[1]广元市妇幼保健院口腔科,四川广元628000

出　　处：《西部医学》2015年第9期1389-1390,1396,共3页Medical Journal of West China

摘　　要：目的探讨甲硝唑(MN)联合地塞米松(DM)用于预防根管治疗期间急症(EIAE)的临床疗效。方法按入院先后顺序,将196例在口腔门诊行根管治疗的牙根尖周炎患者随机分为观察组与对照组各98例。在行根管准备后,观察组予MN联合DM糊剂根管内封药,而对照组予甲醛甲酚(FC)消毒剂根管内封药。观察并分析封药后24、48和48h后至封药时间结束不同时段各组EIAE发生情况。结果观察组的前磨牙及磨牙急症发生率分别为5.9%和16.7%,均低于对照组的30.6%和41.7%,组间差异均有统计学意义(均P<0.05)。在封药后24、48h内观察组急症发生率分别为7.1%和2.0%,均低于对照组的19.4%和11.2%,组间差异亦有统计学意义(均P<0.05);封药48小时后,观察组急症发生率为1%,而对照组为2%,组间差异无统计学意义(P>0.05)。结论MN联合DM用于预防EIAE,相较于FC能明显降低EIAE的发生率。Objective To explore the clinical efficacy of Metronidazole （MN） combined with dexamethasone （DM） for the prevention of endodontie interappointment emergencies（EIAE）. Methods According to the order of admission, 196 patients with periapical inflammation were randomly divided into observation group and control group （n= 98）. Row after root canal preparation, observation group was treated with metronidazole combination with dexamethasone paste root canal sealing agents, while the control group received formaldehyde cresol （FC） sealed root canal disinfectant drugs. EIAE at different time was observed. Results The incidences of EIAE of bicuspid teeth and molars of observation group （5.9% and 16.7%） were lower than that of control group （30.6% and 41.7%） （P〈0. 05）. The incidences of EIAE of drug sealed in 24h and 48h of observation group （7.1% and 2.0%） were lower than that of control group （19.4% and 11.2%）. The incidences of EIAE of 48h after drug sealed of the two groups were not different （P〉0. 05）. Conclusion Compared with FC,MN combined with DM can significantly reduce the incidence of EIAE.

关 键 词：地塞米松 甲硝唑 根管治疗 防治 急症反应 

分 类 号：R781.33[医药卫生—口腔医学]