D二聚体、降钙素原与晚期恶性肿瘤患者静脉血栓栓塞症的相关研究  

The Correlation of D-dimer and Procalcitonin in Malignant Patients with Venous Thromboembolism

作　　者：张艳玲[1] 张宗城[1] 

机构地区：[1]广州医科大学荔湾医院肿瘤科,广州510170

出　　处：《血栓与止血学》2015年第4期215-217,共3页Chinese Journal of Thrombosis and Hemostasis

基　　金：广州市荔湾区科技计划项目资助;课题编号20141216056

摘　　要：目的探讨晚期恶性肿瘤患者静脉血栓栓塞症(VTE)与D二聚体(D-D)及降钙素原(PCT)的相关性。方法选取89晚期恶性肿瘤,根据其是否发生VTE分为两组,栓塞组31例,非栓塞组58例,所有患者入院后1周内检测血浆中D-D和PCT的含量。结果栓塞组的D-D明显高于非栓塞组,PCT栓塞组高于非栓塞组,两组比较有显著性差异(P<0.05),栓塞组中死亡患者的D-D明显高于非死亡患者,但PCT无明显差异;在合并肺部感染及曾经化疗过的患者D-D明显高于无肺部感染及未化疗过的患者,在合并肺部感染的晚期肿瘤患者PCT明显高于无肺部感染的患者,两组比较有显著性差异(P<0.05)。结论血浆D-D对于晚期恶性肿瘤血栓栓塞症(VTE)有一定诊断价值;联合检查D-D、PCT在晚期恶性肿瘤VTE患者预后判断方面有所裨益。Objective To investignate the correlation of D-dimer and Procalcitonin with in malignant patients complicated with venous thromboembolism（VTE）. Methods One eighty-nine malignants were divid- ed into two groups ： embolization group （ 31 cases with VTE ） and nonembolization group （ 58 cases without VTE）. The plasma D-dimer and Procalcitonin were tested in all patients in the first week. Results D-dimer and Procalcitonin in plasma of patients with VTE was more higher than patients without VTE, P 〈 0. 05. D-dimer in the death patients with VTE was higer than the patients alive. D-dimer in the patients with pneumonia and chemotherapy was higher than without pneumonia and chemotheray. Conclusion D-dimer have diagnostic value for VTE in malignant patients. D-dimme and Procalcitonin have impotant clinical prognosis for VTE in malignant patients.

关 键 词：肿瘤 静脉血栓栓塞症 D二聚体 降钙素原 

分 类 号：R73[医药卫生—肿瘤]