血清EB病毒抗体水平与鼻咽癌患者预后的关系  

Relationship between serum EB virus antibody level and prognosis in patients with nasopharyngeal carcinoma

作　　者：令狐颖[1] 苗燕[1] 谢枫[1] 胡德峰[1] 

机构地区：[1]贵州省人民医院体检中心,贵阳550002

出　　处：《检验医学与临床》2015年第17期2490-2493,共4页Laboratory Medicine and Clinic

基　　金：贵州省科技厅基金项目(黔科合SY字[2011]007号)

摘　　要：目的分析治疗前EB病毒Zta-IgA与VCA-IgA抗体浓度与鼻咽癌预后的关系。方法选取2009年2月至2011年2月收治的130例EB病毒Zta-IgA与VCA-IgA抗体阳性患者。根据抗体浓度分为低浓度组（1∶5～1∶20）、中浓度组（1∶40～1∶80）和高浓度组（〉1∶160）。随访36个月,计算并比较各组患者生存情况。结果不同抗体浓度组,临床分期和分化程度之间差异有统计学意义（P〈0.05）。Zta-IgA抗体低、中、高滴度组的放疗近期总有效率分别为90.32%、68.57%、51.56%,差异具有统计学意义（χ2=20.199,P=0.003）。VCA-IgA抗体低、中、高滴度组的放疗近期总有效率分别为90.91%、71.88%、49.23%,差异具有统计学意义（χ2=26.370,P=0.000）。Zta-IgA抗体高滴度组、中滴度组、低滴度组平均生存时间分别为（23.78±1.10）、（27.39±2.45）、（31.11±2.10）个月,差异具有统计学意义（χ2=6.122,P=0.047）。VCA-IgA抗体高滴度组、中滴度组、低滴度组平均生存时间分别为（23.62±1.48）、（26.96±2.55）、（31.54±1.96）个月,差异具有统计学意义（χ2=6.857,P=0.032）。结论 EB病毒Zta-IgA及VCA-IgA抗体水平与鼻咽癌患者放疗的近期疗效以及远期生存情况相关,是鼻咽癌患者预后的独立危险因素。Objective To analyze the relationship between EB virus Zta‐IgA and VCA‐IgA antibody concen‐trations with the prognosis of nasopharyngeal cancer（NPC） .Methods 130 NPC patients with EB virus Zta‐IgA and VCA‐IgA antibody‐positive from February 2009 to February 2011 were selected and divided into the low concentra‐tion group （1∶5-1∶20） ,middle concentration group （1∶40 -1∶80） and high concentration group （〉1∶160） according to the antibody concentration .The 36‐month follow‐up was performed .The survival rates were calculated and compared among 3 groups .Results There was statistically significant differences in clinical stages and degrees of differentiation among different groups（P〈0 .05） .The short term effective rates in the low ,middle and high Zta‐IgA antibody concentration groups were 90 .32% ,68 .57% and 51 .56% respectively ,the differences were statistically sig‐nificant （χ2 = 20 .199 ,P= 0 .003） .The total short term effective rate of radiotherapy in the low ,middle and high VCA‐IgA antibody concentration groups were 90 .91% ,71 .88% ,49 .23% respectively ,the differences were statisti‐cally significant（χ2 = 26 .370 ,P=0 .000） .The average survival time in the high ,middle and low Zta‐IgA antibody concentration groups were （23 .78 ± 1 .10） ,（27 .39 ± 2 .45） ,（31 .11 ± 2 .10） months respectively ,the differences were statistically significant（χ2 =6 .122 ,P=0 .047） .The average survival time in the high ,middle and low VCA‐IgA anti‐body concentration group were （23 .62 ± 1 .48） ,（26 .96 ± 2 .55） ,（31 .54 ± 1 .96） months ,the differences were statisti‐cally significant （χ2 = 6 .857 ,P= 0 .032） .Conclusion EB virus Zta‐IgA and VCA‐IgA antibody levels are related with the short‐term efficacy and long‐term survival of the NPC patients and the independent risk factors for the prog‐nosis of the NPC patients .

关 键 词：鼻咽癌 EB病毒 抗体 预后 

分 类 号：R739.63[医药卫生—肿瘤]