腹腔热灌注联合新辅助化疗在提高晚期上皮性卵巢癌二次减灭术有效率中的作用  

Role of continuous hyperthermic peritoneal perfusion chemotherapy combined with intravenous chemotherapy in improving the therapeutic effect of interval cytoreduction on advanced epithelial ovary carcinoma

作　　者：陈小辉[1,2] 李雅丽[1,2] 

机构地区：[1]郑州大学人民医院 [2]河南省人民医院妇产科,郑州450003

出　　处：《中华实用诊断与治疗杂志》2015年第9期929-931,共3页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨高精度持续循环腹腔热灌注(continuous hyperthermic peritoneal perfusion chemotherapy,CHPPC)联合新辅助化疗在提高初次肿瘤减灭术疗效不佳的晚期卵巢癌患者二次肿瘤细胞减灭术成功率及疗效中的作用。方法初次肿瘤减灭术疗效不佳晚期卵巢癌患者60例,随机分为对照组28例和观察组32例,对照组应用PT(紫杉醇+奥沙利铂)方案化疗3个周期后行二次肿瘤细胞减灭术;观察组初次肿瘤细胞减灭术后第1,3,5天行CHPPC,1周后行PT化疗3个周期,然后行二次肿瘤细胞减灭术,比较2组二次肿瘤细胞减灭术有效率及疗效,并观察不良反应发生情况。结果观察组二次肿瘤细胞减灭术有效率(89.29%)高于对照组(75.00%)(P<0.05),治疗总有效率(82.14%)高于对照组(62.50%)(P<0.05),不良反应发生率(53.57%)与对照组(53.12%)比较差异无统计学意义(P>0.05)。结论 CHPPC联合新辅助化疗用于初次肿瘤减灭术疗效不佳的晚期卵巢癌患者,可提高二次肿瘤细胞减灭术有效率及疗效,且不增加不良反应发生率。Objective To explore the role of continuous hyperthermic peritoneal perfusion chemotherapy （CHPPC） combined with intravenous chemotherapy in improving the therapeutic effect of interval cytoreduction on advanced epithelial ovary carcinoma after unsatisfied initial cytoreductive surgery. Methods Sixty patients with advanced epithelial ovary carcinoma after unsatisfied initial cytoreductive surgery were randomly divided into observation group （n=32） and control group （n=28）. Observation group received interval cytoreduction after CHPPC by day 1, 3 and 5 after operation and intravenous chemotherapy 1 week later. Control group received interval cytoreduction after chemotherapy with paclitaxel and oxaliplatin for 3 cycles. The success rate and effective rate were compared between two groups and the adverse reactions were observed. Results The success rate and total effective rate were 89. 29% and 82. 14% in observation group, significantly higher than that in control group （75. 00%, 62. 50%） （P〈 0.05）. There was no significant difference in the incidence of adverse reactions between observation group （53. 57%） and control group （53.12 %） （P^0.05）. Conclusion CHPPC combined with intravenous chemotherapy can improve the effective rate and success rate of interval chemotherapy for advanced epithelial ovary carcinoma after unsatisfied initial cytoreductive surgery, without increasing the incidence of adverse reactions.

关 键 词：晚期卵巢上皮癌 新辅助化疗 高精度持续循环腹腔热灌注联合静脉化疗 二次肿瘤细胞减灭术 

分 类 号：R737.31[医药卫生—肿瘤]