肝动脉化疗栓塞联合射频消融治疗原发性肝癌的疗效及安全性  

Efficacy and safety of transcatheter arterial chemoembolization combined with radiofrequency ablation in the treatment of primary liver cancer

作　　者：王晓[1] 孙建明[1] 肖兵[1] 

机构地区：[1]四川省达州市中心医院消化内科,达州635000

出　　处：《中国肿瘤临床与康复》2015年第9期1068-1070,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨肝动脉化疗栓塞联合射频消融治疗原发性肝癌的临床疗效及安全性。方法选取2011年1月至2014年9月间收治的100例原发性肝癌患者,根据随机数字表法分为观察组和对照组,每组50例,观察组患者接受肝动脉化疗栓塞联合射频消融治疗,对照组患者接受肝动脉化疗栓塞治疗。观察和比较两组患者治疗后的临床疗效、肿瘤坏死程度、术后6个月肿瘤复发率、生存率以及不良反应发生情况。结果观察组患者的治疗总有效率和肿瘤完全坏死率明显高于对照组(P<0.05)。平均随访6个月,观察组患者肿瘤复发率明显低于对照组,生存率显著升高(P<0.05)。两组患者治疗期间均未出现严重不良反应。结论肝动脉化疗栓塞联合射频消融治疗原发性肝癌的疗效显著,可明显提高肿瘤坏死率及生存率,不良反应少,安全性好。Objective To study the clinical efficacy and safety of transcatheter arterial chemoembolization combined with radiofrequency ablation in the treatment of primary liver cancer. Methods 100 primary liver cancer patients in Dazhou Central Hospital during January 2011 to September 2014 were enrolled in the study and randomized into the observation group and the control group according to the random number method,50 cases in each group. The observation group accepted transcatheter arterial chemoembolization combined with radiofrequency ablation and the control group accepted transcatheter arterial chemoembolization. The clinical efficacy,degree of tumor necrosis,tumor recurrence rate,survival rate on 6 mo after surgery and the adverse reactions between the two groups were ompared. Results Compared with the control group,the total effective rate of treatment was significantly increased in the observation group（ P〈0. 05）; the complete necrosis rate of tumor was significantly increased and the rates of incomplete necrosis were obviously decreased in the observation group（ P〈0. 05）; the tumor recurrence rate was significantly reduced and the survival rate was obviously increased on 6 mo after surgery in the observation group（ P〈0. 05）. There were no serious adverse reactions in the two groups during the treatment. Conclusion The treatment of transcatheter arterial chemoembolization combined with radiofrequency ablation for primary liver cancer could achieve good efficacy,and increase the tumor necrosis rate and survival rate,with less adverse reaction and higher safety.

关 键 词：肝肿瘤 肝动脉化疗栓塞 射频消融 安全性 

分 类 号：R735.7[医药卫生—肿瘤]