乳腺浸润性导管癌组织中p-AKT、VEGF-C的表达及其与侵袭、转移的关系  

Study on the relation of expression of p-AKT,VEGF-C with the lymph node invasion and metastasis of breast invasive ductal carcinoma

作　　者：刘君[1] 黄凤德[1] 胡晋太[1] 岳明全[1] 

机构地区：[1]四川绵阳四O四医院,四川绵阳621000

出　　处：《现代中西医结合杂志》2015年第27期2968-2970,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨乳腺浸润性导管癌(IDC)组织磷酸化蛋白激酶B(p-AKT)、血管内皮细胞生长因子-C(VEGF-C)表达水平,及其与淋巴结侵袭转移的关系。方法应用免疫组织化学法检测72例乳腺IDC组织及30例乳腺腺瘤组织中p-AKT、VEGF-C的表达水平,分析p-AKT与血管生成的关系。结果乳腺IDC组织中VEGF、p-AKT蛋白的阳性表达率分别为59%和67%,均显著高于乳腺腺瘤组织中20%和17%的阳性表达率(X2=13.39,21.21,P<0.05);与有淋巴结转移者比较,无淋巴结转移的乳腺IDC组织VEGF-C、pAKT蛋白阳性表达率显著降低(X2=11.10,5.51,P<0.05);乳腺IDC组织VEGF-C、pAKT蛋白表达水平呈显著正相关(r=0.823,P<0.05)。结论乳腺IDC组织中VEGF-C、pAKT呈过度表达状态,共同参与淋巴结的侵袭与转移,阻断PI3K/AKT通路有望为乳腺IDC的靶向治疗提供一种新的思路。Objective It is to investigate the expression of vascular endothelial growth factor （ VEGF）, protein kinase B （P- AKT） in breast invasive ductal carcinoma （IDC） , and its relation with lymph node invasion and metastasis. Methods The expression of p - AKT, VEGF - C in the tissue of 72 cases of breast IDC and 30 cases of breast fibroadenoma were detec- ted by immunohistochemical staining, the correlation between p -AKT and angiogenesis were analyzed. Results The positive expression rate of p -AKT, VEGF- C protein in breast IDC was 59% and 67% respectively, which was significantly higher than that in breast fibroadenoma of 20% and 17% respectively （ χ 2= 13.39, 21.21, all P 〈 0. 05）. The expressions of p - AKT, VEGF - C in breast IDC with lymphnode metastasis were higher than those without lymphnode metastasis （χ2= 11.10, 5.51, all P 〈 0. 05）. The positive expression rate of VEGF- C had significant positive correlation with that of p -AKT （r = 0. 823, P 〈0.05 ）. Conelttsion The expression of p- AKT, VEGF- C in breast IDC is over-expressive, and participate the lymphnode invasion and metastasis. Inhibition of PI3K/AKT signal transduction pathway can be expected to provide a new method for the target therapy of breast IDC.

关 键 词：乳腺浸润性导管癌 血管内皮细胞生长因子-C 磷酸化蛋白激酶B 淋巴结转移 

分 类 号：R737.9[医药卫生—肿瘤]