丁苯酞对脑卒中睡眠障碍患者血清性激素、5-羟色胺及睡眠质量的影响  

Effect of butylphthalide on serum sex hormone,5-HT and sleep quality in patients with stroke sleep disorder

作　　者：陈汉水[1] 童绥君[1] 马琪琳 

机构地区：[1]厦门大学附属第一医院神经内科,福建厦门361000

出　　处：《中国生化药物杂志》2015年第6期52-54,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：福建省科技厅2013年度科研立项基金(2013FK0917)

摘　　要：目的探讨丁苯酞对脑卒中睡眠障碍患者血清性激素、5-羟色胺(5-hydroxytryptamine,5-HT)及睡眠质量影响。方法选取神经内科收治的脑卒中患者240例,按用药不同随机分为2组,每组各120例,对照组患者给予临床常规治疗,实验组在其基础上给予丁苯酞软胶囊。治疗结束后检测2组患者的血清性激素、5-HT以及匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)水平。结果与对照组相比,实验组患者的促卵泡成熟激素(follicle-stimulating hormone,FSH)、促黄体生成素(luteinizing hormone,LH)水平较高,雌二醇(estradiol,E2)水平较低(P<0.05),血清5-TH水平较高(P<0.05),PSQI评分较低(P<0.05),差异具有统计学意义。结论丁苯酞能够改善脑卒中睡眠障碍患者血清性激素与5-HT水平,改善睡眠质量,对临床治疗该病具有指导意义。Objective To investigate effect of butylphthalide on serum sex hormone,5-HT and sleep quality in patients with stroke sleep disorder. Methods 240 patients with stroke sleep disorder in our hospital were selected,according to clinical medication were divided into 2 groups.Control group （n=120） were treated by routine treatment, experimental group （n=120） was treated on the base of the control group with butylphthalide.Serum sex hormones, 5-HT and PSQI levels were detected after the treatment.Results Compared with the control group,LH, FSH levels of the experiment were higher（P〈0.05）,E2 level was lower（P〈0.05）,serum 5-TH level was higher（P〈0.05）,PSQI score was lower（P〈0.05）,the difference was statistically significant.Conclusion Butylphthalide can improve stroke sleep disorder serum sex hormone and 5-HT levels, improve sleep quality, has guiding significance for the treatment.

关 键 词：丁苯酞 脑卒中睡眠障碍 性激素 5-羟色胺 PSQI 

分 类 号：R743[医药卫生—神经病学与精神病学]