博宁霉素对宫颈人乳头瘤病毒感染患者L1壳蛋白表达及血清免疫因子水平的影响  

Effect of boningmycin on expression of capsid protein L1 and serum immune factors in cervical HPV infection patients

作　　者：黄孟启 陈爱增 蔡文品[2] 

机构地区：[1]苍南县第三人民医院检验科,浙江温州325804 [2]温州市中医院检验科,浙江温州325000

出　　处：《中国生化药物杂志》2015年第6期59-61,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：苍南县科技计划项目(2013823)

摘　　要：目的探讨博宁霉素对宫颈人乳头瘤病毒感染L1壳蛋白的表达及其免疫效果。方法选取宫颈人乳头瘤病毒感染患者60例,根据用药不同分为实验组和对照组,每组各30例,对照组患者给予重组人干扰素α2b,10万IU/次,隔天1次,经期停用;实验组患者给予博宁霉素300 mg肌肉注射,隔天1次。治疗10次为1个疗程,连续2个疗程。治疗结束后比较患者HPVL1壳蛋白,血清TNF-α、IL-2、IFN-α水平以及HPV的阳性率。结果治疗后,与对照组比较,实验组患者HPVL1壳蛋白百分比明显上升(P<0.05),实验组患者TNF-α、IFN-α水平升高(P<0.05),IL-2水平降低(P<0.05),实验组患者HPV的阳性率降低(P<0.05)。结论博宁霉素能够降低宫颈人乳头瘤病毒感染患者L1壳蛋白百分比,升高血清TNF-α、IFN-α水平,降低IL-2水平,降低HPV的阳性率。Objective To investigate the effect of boningmycin on expression of capsid protein L1 and serum immune factors in cervical HPV infection patients.Methods 60 patients with cervical HPV infection were divided into experimental group and control group, 30 cases in each group.The control group were given recombinant human interferon α2b suppository, 100 000 IU, once every other day, and the experiment group were given boningmycin 300 mg intramuscular injection,once every other day.Treatment of 10 times for a course,2 consecutive courses After treatment, the HPV capsid protein L1, serum TNF-α, IL-2, IFN-αand HPV were compared.Results Compared with control group after treatment, the percentage of HPV capsid protein L1 increased （ P 〈0.05 ） , serum TNF-α, IFN-αlevels increased （ P 〈0.05 ） , IL-2 decreased （ P 〈0.05 ） , and HPV positive rate decreased（ P 〈0.05 ）.Conclusion Boningmycin could reduce the percentage of capsid protein L1 in patients with cervical human papilloma virus infection, elevate serum TNF-αand IFN-αlevels, reduce the level of IL-2 and HPV positive rate.

关 键 词：博宁霉素 人乳头瘤病毒 L1壳蛋白 免疫功能 

分 类 号：R737.3[医药卫生—肿瘤]