硝普钠缓释对垂体瘤术后认知功能、S-100β蛋白与视锥蛋白样蛋白-1影响  

Effect of sodium nitroprusside sustained release on cognitive function,S-100β protein and visinin-like protein 1 in pituitary tumor surgery patients

作　　者：邱华辉[1] 张增辉[1] 蒋峰[1] 

机构地区：[1]浙江省舟山医院神经外科,浙江舟山316021

出　　处：《中国生化药物杂志》2015年第6期83-85,88,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的：探讨硝普钠缓释对垂体瘤切除术后认知功能、S-100β蛋白与视锥蛋白样蛋白-1影响。方法选取神经外科确诊为垂体瘤的老年患者156例，通过随机数字表方法将其平均分为实验组和对照组，每组各78例，患者均行全身麻醉诱导，实验组在手术开始时采用微量泵以0.5～6.0μg／（ kg· min）泵入硝普钠降压。术前1天和术后2天采用简易精神状况检查量表（ mini-mental state examination，MMSE）评分测定2组患者的认知功能，并采用酶联免疫吸附法测定麻醉前、术毕、术后12、24、48 h血清中S-100β蛋白和视锥蛋白样蛋白-1（ visinin-like protein 1，VILIP-1）含量。结果2组术后认知障碍发生率比较无统计学意义；与对照组相比，实验组手术时间、出血量以及苏醒时间均较低（P＜0.05）；患者术后血清中S-100β蛋白和VILIP-1水平均呈现先上升后下降的趋势，在术后24 h达到高峰，与认知正常组患者同期比较，认知障碍组血清中S-100β蛋白和VILIP-1水平较高（ P＜0.05）；与对照组同期比较，实验组血清中S-100β蛋白和VILIP-1水平较低（ P＜0.05）。结论采用硝普钠缓释控制性降压能够减轻患者的认知障碍水平，降低患者的S-100β蛋白与视锥蛋白样蛋白-1，对临床具有一定的指导意义。Objective To investigate the effect of sodium nitroprusside sustained release on cognitive function, S-100βprotein and VILIP-1 in pituitary tumor surgery patients.Methods 156 cases of pituitary tumor patients were selected and divided into two groups according to random number table method,78 patients in each group.All patients underwent general anesthesia induction,the experimental group treated with 0.5~6 μg （ kg· min） infusion of sodium nitroprusside induced hypotension by micro pump at the beginning of operation.MMSE was used to determine the cognitive function of 2 groups of patients 1 day before operation and 2 days after operation,S-100βand VILIP-1 content were determined by ELISA before anesthesia,after surgery,and 0,12,24,48 h after operation.Results There was no statistical significance between the 2 groups in the incidence of postoperative cognitive dysfunction.Compared with control group, the operation time, bleeding volume and the recovery time of the experiment group were lower（P〈0.05）.S-100βprotein and VILIP-1 showed increased at first and then decreased at the peak of 24h;compared with the normal group, the levels of S-100βprotein and VILIP-1 of the cognitive impairment were higher （ P 〈0.05 ）.Compared with the control group, the levels of S-100βprotein and VILIP-1 of the experiment group were lower（P 〈0.05）.Conclusion Sodium nitroprusside sustained release controlled hypotension can reduce the level of cognitive disorder, patients of S-100βprotein and visinin-like protein 1 and has certain directive significance to the clinical.

关 键 词：垂体瘤 硝普钠缓释 认知功能 S-100Β蛋白 视锥蛋白样蛋白-1 

分 类 号：R739.41[医药卫生—肿瘤]