小檗碱对卵巢癌患者外周血D-二聚体、FIB与IL-6变化的研究  

Effect of berberine on D-dimer,fibrinogen and interleukin-6 in peripheral blood of ovarian cancer patients

作　　者：范凌晔[1] 石磊[2] 汪春燕[1] 詹平[1] 任黔川[1] 

机构地区：[1]泸州医学院附属医院妇产科,四川泸州646000 [2]泸州医学院附属医院人事科,四川泸州646000

出　　处：《中国生化药物杂志》2015年第6期114-117,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨小檗碱对卵巢癌患者外周血D-二聚体、纤维蛋白原(fibrinogen,FIB)水平与白细胞介素-6(interleukin-6,IL-6)变化的影响。方法选取泸州医学院附属医院肿瘤科已确诊为单侧卵巢癌患者130例,均给予手术、化疗治疗,分为对照组(25例)和实验组(105例),实验组随机分为A、B、C3组,每组各35例,实验组在常规化疗的基础上予盐酸小檗碱片每天3次口服,实验组根据服用剂量分为:A组:0.3 g,B组:0.2 g,C组:0.1 g,每组35例,连续服用2周;治疗前后检测各组患者外周血D-二聚体、FIB与IL-6水平以及生活质量评分。结果治疗后,实验组各组患者外周血D-二聚体含量均低于对照组,且A组<B组<C组(均P<0.05);实验组各组患者外周血FIB含量均低于对照组,且A组<C组(均P<0.05),但A、C组与B组比较差异均无统计学意义;A、B组患者外周血IL-6含量均低于对照组(均P<0.05),但C组IL-6含量与对照组比较差异无统计学意义,且A、B组<C组(均P<0.05),但A组与B组比较差异无统计学意义;A、B组患者生活质量评分均低于对照组(均P<0.05),但C组生活质量评分与对照组比较差异无统计学意义,且A组<C组(P<0.05),但A、C组与B组比较差异均无统计学意义。结论大剂量小檗碱能够降低卵巢癌患者外周血D-二聚体、FIB与IL-6水平,提高患者生活质量,且呈剂量依赖性。Objective To analyse the effect of berberine on D-dimer, fibrinogen （FIB） and interleukin-6（IL-6） in peripheral blood of ovarian cancer patients.Methods 130 cases selected from the hospital were diagnosed as unilateral ovarian cancer, treated by surgery and chemotherapy.The patients were divided into control group （25 cases） and experimental group （105 cases）, and the experimental group were randomly divided into A, B, C three groups, 35 cases in each group.The experimental group received berberine hydrochloride tablets, orally, three times a day, on the basis of conventional chemotherapy.The experimental groups were divided into three subgroups according to the dosage： A group： 0.3 g, B group： 0.2 g, C group：0.1 g, 35 cases in each group, continuously treated for 2 weeks.The levels of D-dimer, FIB and IL-6 and quality of life score were detected before and after treatment.Results After treatment, D-dimer level in each subgroup of experimental group was lower than that in control group, respectively, and A group〈B group〈C group （all P〈0.05）; FIB level in each subgroup of experimental group was lower than that in control group, respectively, and A group 〈C group （all P〈0.05）, while there were no significant differences between A or C group and B group; IL-6 levels in A and B group were lower than that in control group, respectively, but there was no significant difference between C group and control group, and A and B group 〈C group （all P〈0.05）, while there was no significant difference between A and B group;quality of life scores in A and B group were lower than that in control group （P〈0.05）, while there was no significant difference between C group and control group, and A group 〈C group （P〈0.05）, but there were no significant differences between A or C group and B group.Conclusion Berberine could reduce the levels of D-dimer, FIB and IL-6 in peripheral blood of ovarian cancer patients and improve the quality of life, with the dose-dependence.

关 键 词：卵巢癌 小檗碱 D-二聚体 纤维蛋白原 白细胞介素-6 

分 类 号：R737.31[医药卫生—肿瘤]