miR-1202通过调控小鼠脑内的mGluR_4的表达在重度抑郁症中的作用  

Effect of miR-1202 on severe depression by regulating mGluR_4 expression in brain of mice

作　　者：雷辉[1] 顾乃兵[1] 刘志勤[1] 常明则 

机构地区：[1]西安市中心医院神经内科,西安710003

出　　处：《陕西医学杂志》2015年第9期1109-1111,共3页Shaanxi Medical Journal

基　　金：陕西省自然科学基础研究计划项目(2014JM4162);陕西省科技发展计划资助项目(2014K110203)

摘　　要：目的:探讨miR-1202在重度抑郁症中的作用及机制。方法:使用过表达miR-1202的腺相关病毒和慢性不可预见性应激模型的小鼠,通过旷场实验和强迫游泳实验等行为学实验来评估miR-1202的作用;通过Western-Blot实验来验证miR-1202的分子机制。结果:在抑郁症模型小鼠海马区域中过表达miR-1202发现抑郁症症状有所缓解,WB检测实验验证miR-1202的靶基因为mGluR4。结论:在小鼠海马区域中的miR-1202通过mGluR4参与了重度抑郁症,这为未来治疗抑郁症提供了一个新的靶点。Objective：To investigate the the effect of over expression of miR-1202 on severe depression.Methods：We evaluated the role of miR-1202 in the open field test and forced swimming test and other behavioral experiments in chronic unpredictable stress model mice and we also used Western Blot to verify the molecular mechanism of miR-1202. Results：Over expression of miR-1202 was found to relieve depressive symptoms in mouse,the expression of mGluR4 decreased miR-1202 expressed in mouse.Conclusion：In hippocampus of mice,miR-1202 relieve depression symptom by decreasing the expression of mGluR4,which provides a new target for future therapy for the treatment of depression.

关 键 词：抑郁症/治疗 抑郁症/病理生理学 海马 基因/治疗应用 模型 动物 小鼠 @miR-1202 @mGluR4 

分 类 号：R749.4[医药卫生—神经病学与精神病学]