趋化因子受体4和趋化因子受体7在胃癌组织中的表达及其临床意义  

Expressions and Clinical Significance of Chemokines Factor Receptors 4 and Chemokines Factor Receptors 7 in Gastric Cancer Tissues

作　　者：杨婧[1] 黄显斌[1] 郝相勇[1] 魏丽[1] 景武堂[1] 郭天康[1] 

机构地区：[1]甘肃省人民医院普外一科,甘肃兰州730000

出　　处：《中国普外基础与临床杂志》2015年第9期1062-1067,共6页Chinese Journal of Bases and Clinics In General Surgery

基　　金：甘肃省自然科学基金(项目编号:1308RJZA252)~~

摘　　要：目的探索趋化因子受体4（CXCR4）和趋化因子受体7（CXCR7）在胃癌组织和正常胃组织中的表达及其临床意义。方法回顾性收集2011年1月至2013年6月期间于甘肃省人民医院普外一科行胃癌根治术、并经术后病理学检查证实为胃癌的65例患者的临床资料（胃癌组），同期收集甘肃省人民医院普外一科收治的行胃大部切除术的20例胃溃疡患者的临床资料（对照组）。采用免疫组织化学染色方法检测胃癌组癌组织和对照组正常胃组织中CXCR4和CXCR7的表达，并探索CXCR4和CXCR7在胃癌组织中的表达与胃癌患者临床病理学特征之间的关系，及其表达对胃癌患者预后的影响。结果胃癌组组织中CXCR4的表达阳性率为80．00％（52／65），CXCR7为84．62％（55／65），分别高于对照组的5．00％（1／20）和10．00％（2／20），差异均有统计学意义（x^2=36．65，P〈0．01；x^2=38．55，P〈O．01）。CXCR4的表达与胃癌的分化程度、T分期及TNM分期均相关（P〈0．05），分化程度低、T3-4期及Ⅲ。Ⅳ期者的CXCR4表达阳性率相应高于分化程度为中／高、T1～2期和Ⅰ～Ⅱ期者；CXCR7的表达与分化程度、T分期及N分期均相关（P〈0．05），分化程度低、T3～4期及N1～3期者的CXCR7表达阳性率相应高于分化程度为中，高、T1～2期和NO期者。CXCR4表达阴性胃癌患者和CXCR7表达阴性胃癌患者的预后分别好于CXCR4表达阳性者（P=0．01）和CXCR7表达阳性者（P=0．01）。结论CXCR4和CXCR7表达与胃癌的发生和发展均有关，可作为预测胃癌预后的标志物。CXCR4／趋化因子12（CXCL12）轴和CXCR7／CXCL12轴可作为胃癌治疗的靶点，从而为胃癌的治疗提供了一个新的思路和方法。Objective To investigate the expressions and significance of chemokines factor receptors 4 （CXCR4） and chemokines factor receptors 7 （CXCR7） in gastric cancer tissues. Methods Sixty-five patients with gastric cancer who treated in our hospital from January 2011 to June 2013 were retrospectively collected as gastric cancer group, and 20 patients with gastric ulcer were retrospectively collected as control group at the same time. The expressions of CXCR4 and CXCR7 in gastric cancer tissues and normal gastric tissues were measured by immunohistochemistry, and then the relation- ship among expressions of CXCR4/CXCR7 in gastric cancer tissues and clinicopathological features of patients with gastric cancer was explored, as well as its effect on survival. Results Positive expression rates of CXCR4 and CXCR7 were identi- fied in 80.00% （52/65） and 84.62% （55/65） of the gastric cancer group, and 5.00% （1/20） and 10.00% （2/20） in control group respectively, and the positive expression rates of CXCR4 and CXCR7 in gastric cancer group were significantly higher than those of control group respectively （x^2=36.65, P〈0.01; x^2=38.55, P〈0.01）. The positive expression rate of CXCR4 in gastriccancer tissues was related with degree of differentiation, T staging, and TNM staging （P〈0.05）, positive expression rate of CXCR4 in patients with poor differentiation, T3-4 staging, and TNM Ⅲ-Ⅳ staging were higher than corresponding patients with moderate/high degree of differentiation, T1-2 staging, and TNM Ⅰ-Ⅱ staging. The positive expression rate of CXCR7 in gastric cancer tissues was related with degree of differentiation, T staging, and N staging （P〈0.05）, positive expression rate of CXCR7 in patients with poor differentiation, T3-4 staging, and N1-3 staging were higher than corrsponding patients with moderate/high degree of differentiation, T1-2 staging, and NO staging. The survival situation was worse in patients with positive expression of CXCR4 and CXCR7 than corresponding patient

关 键 词：趋化因子受体4 趋化因子受体7 胃癌 免疫组织化学染色 预后 

分 类 号：R735.2[医药卫生—肿瘤]