脂肪干细胞在脂肪组织修复重建中的应用  

Application of Adipose-Derived Stem Cells for Repairment and Regeneration of Adipose Tissue:A Review

作　　者：张舒[1] 吕青[1] 

机构地区：[1]四川大学华西医院乳腺外科,四川成都610041

出　　处：《中国普外基础与临床杂志》2015年第9期1148-1152,共5页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的总结脂肪干细胞(ADSCs)的分离方法、生物学特性、多向分化能力及其促血管化作用,以探讨其在脂肪组织修复重建中的作用。方法回顾性分析国内外的ADSCs相关文献,探讨其在脂肪组织修复重建中的作用。结果 ADSCs作为人体储量最丰富的间充质干细胞,从体表脂肪组织中分离而来,具有多向分化能力,经诱导可分化为脂肪、软骨、骨、心肌、肌肉、血管上皮细胞等多种组织细胞,其中其成脂分化能力可保持数代不衰减。ADSCs还具有旁分泌功能,分泌血管上皮生长因子、成纤维细胞生长因子2(FGF-2)等细胞因子,能促进组织血管化,提高游离脂肪组织移植的存活率。结论 ADSCs可用于脂肪组织工程、脂肪组织移植和软组织创伤修复中,在乳腺组织的修复重建方面具有重要的应用前景。Objective To summarize the isolation procedures, molecular characterization, and differentiation and vascularization capacity of adipose-derived stem cells （ADSCs）, in order to discuss the potential value of ADSCs for the repairment and regeneration of adipose tissues. Methods Related literatures about ADSCs were retrieved to summarize the potential value of ADSCs for the repairment and regeneration of adipose tissues. Results As mesenchymal stem cells, ADSCs was rich in human adipose tissues. ADSCs possessed the potential to differentiate toward a variety of cell lineages, such as adipogenic, chondrogenic, osteogenic, cardiomyogenic, myogenic, and angiogenic. Besides, its capacity of adipogenic differentiation could maintain several passages. The most importantly, ADSCs could secrete significant amounts of angiogenesis-related cytokines, such as vascular endothelial growth factor （VEGF） and fibroblast growth factor-2 （FGF-2）, which increased the angiogenesis of adipose tissue. Condusions ADSCs play a key role in adipose tissue engineering, autologous adipose tissue grafting, and soft tissue wound repairing, which have important application prospect for breast reconstruction.

关 键 词：脂肪干细胞 组织工程 脂肪细胞 脂肪组织 

分 类 号：R737.9[医药卫生—肿瘤]