弥漫性血管内凝血评分、纤维蛋白原含量对急性脑梗死患者预后评估的价值  

Value of disseminated intravascular coagulation score and fibrinogen in the assessment of prognosis for acute cerebral infarction in the elderly patients

作　　者：付洪伟[1] 李嫚[2] 

机构地区：[1]枣阳市第一人民医院神经内科,湖北省枣阳市441200 [2]华中科技大学同济医学院附属协和医院神经内科,湖北省武汉市430074

出　　处：《实用老年医学》2015年第8期653-655,共3页Practical Geriatrics

摘　　要：目的探讨弥漫性血管内凝血(DIC)评分、血浆纤维蛋白原(FIB)含量在急性脑梗死患者预后评估中的价值。方法选择2012年8月至2013年8月我院收治的58例急性脑梗死患者作为研究组,并选择同期在我院体检中心体检的50例健康人群作为对照组;比较对照组及研究组患者DIC评分、D-二聚体、血浆FIB含量以及部分凝血酶原时间(APTT)。结果急性脑梗死患者DIC评分、FIB、D-二聚体显著高于对照组,APTT明显缩短,2组间比较差异具有统计学意义(P<0.05或0.01);大面积梗死、有意识障碍以及死亡患者DIC评分、FIB、D-二聚体显著升高,APTT明显缩短(P<0.05或0.01)。结论 DIC评分、血浆D-二聚体和FIB含量在脑梗死患者病情判断、预后评估、治疗指导中有着重要的意义,可以作为急性脑梗死患者诊治的有效检验指标。Objective To explore the value of disseminated intravascular coagulation（DIC） score and fibrinogen（FIB） in evaluating the prognosis of acute cerebral infarction in the elderly patients.Methods Fifty-eight elderly patients with acute cerebral infarction from August 2012 to August 2013 in our hospital were enrolled as study group,and 50 healthy people undergoing health examination in our hospital were selected as control group.The levels of DIC scores,Ddimmer,FIB and prothrombin time（APTT） were determined and compared between the two groups.Results The levels of DIC score,FIB,D-dimmer in study group were significantly higher than those in control group,and the level of APTT was significantly lower（P〈0.05 or 0.01）.The patients with large infarction area or disturbance of consciousness and the dead patients showed higher level of DIC score,FIB,D-dimer,and lower level of APTT（P〈0.05 or 0.01）.Conclusions DIC score,plasma D-dimmer and FIB show great significance in disease judge,prognosis,treatment guidance for cerebral infarction,which can be used as effective index in diagnosis and treatment for acute cerebral infarction.

关 键 词：弥漫性血管内凝血评分 纤维蛋白原 D-二聚体 急性脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]