垂体柄中断综合征11例临床分析  

Clinical analyses of 11 cases with pituitary stalk interruption syndrome

作　　者：张颖辉[1] 王冰[2] 李志臻[1] 马晓君[1] 樊大贝[1] 秦贵军[1] 

机构地区：[1]郑州大学第一附属医院内分泌科,450052 [2]河南中医学院第一附属医院血液肿瘤科

出　　处：《中华全科医师杂志》2015年第9期691-694,共4页Chinese Journal of General Practitioners

摘　　要：回顾分析我院收治的11例垂体柄中断综合征（PSIS）患者的临床表现.11例均为男性,临床表现为不同程度的生长发育障碍.所有患者存在生长激素缺乏、低促性腺激素性性腺功能减退;8例同时存在中枢性甲状腺功能减退和肾上腺皮质功能减退,1例合并中枢性尿崩症,垂体MRI增强扫描：垂体柄缺如或纤细,垂体小,后叶异位.提示PSIS以生长迟缓和性腺发育不良为主要临床表现,部分性或完全性垂体前叶功能减退,垂体MRI检查为重要诊断依据.Eleven male patients with pituitary stalk interruption syndrome （PSIS） at our hospital were retrospectively analyzed with respects to clinical features,endocrine status and imaging characteristics.The clinical manifestations included growth retardation and delayed puberty.All of them were deficient in growth hormone and pituitary gonadotropin secretion.Secondary hypothyroidism and hypocortisolism occurred in 8 patients and one had concurrent central diabetes insipidus.MRI with gadolinium contrast revealed no pituitary stalk or slim and anterior pituitary hypoplasia with ectopic posterior pituitary.The clinical characteristics of PSIS are growth retardation and delayed puberty,partial or complete adenohypophyseal dysfunction.The detection of hypothalamic pituitary region by MRI is an important diagnostic tool.

关 键 词：垂体疾病 垂体柄中断综合征 

分 类 号：R584[医药卫生—内分泌]