细胞角蛋白19-2G2对恶性肿瘤诊断价值的探讨  

Investigation on the diagnostic value of cell keratin 19-2G2 for the malignant tumor

作　　者：邸晓辉[1] 徐娟[1] 郑绯[2] 贾志凌[1] 

机构地区：[1]北京军区总医院药理科,北京100700 [2]解放军302医院药学部,北京100039

出　　处：《中国卫生检验杂志》2015年第16期2761-2762,2768,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨血清CK19片段检测方法对恶性肿瘤的诊断价值,并与Cyfra21-1进行比较。方法应用CK19-2G2和Cyrfa21-1的检测试剂盒,分别检测恶性肿瘤患者200例(包括肺癌患者51例、胃癌患者34例、膀胱癌患者47例、胰腺癌患者37例、乳腺癌患者31例)、良性病变患者110例和健康者113例。结果恶性肿瘤患者CK19-2G2和Cyfra21-1检测结果均显著高于良性病变患者,差异有统计学意义(P<0.05);良性病变患者CK19-2G2和Cyfra21-1检测结果均显著高于健康者,差异有统计学意义(P<0.05)。CK19-2G2诊断肺癌、膀胱癌、胰腺癌及全部恶性肿瘤的灵敏度要高于Cyfra21-1,差异具有统计学意义(P<0.05)。结论通过ROC曲线分析,CK19-2G2对于恶性肿瘤的诊断准确性要优于Cyfra21-1,2种标志物联合检测的诊断准确性要高于单一标志物检测。CK19-2G2可以作为一种广谱性肿瘤标志物对恶性肿瘤进行辅助诊断。Objective To investigate the diagnostic value of serum CK19 fragment detection method for malignant tumors and to compare with Cyfra21- 1. Methods 200 patients with malignant（ including 51 patients with lung cancer,34 patients with gastric cancer,47 patients with bladder cancer,37 patients with pancreatic cancer,31 patients with breast cancer）,110 patients with benign lesions and 113 healthy cases were detected using CK19- 2G2 and Cyrfa21- 1 detection kit. Results The serum of CK19- 2G2 and Cyfra21- 1 levels were significantly elevated in malignant patients compared with patients with benign lesions（ P〈0. 05） and the level in patients with benign lesions was higher than the normal serum and the differences had statistical significance（ P〈0. 05）. The sensitivity of serum K19- 2G2 detection in diagnosis lung cancer,bladder cancer,pancreatic cancer and all malignant tumor were higher than those of Crfra21- 1and the differences had statistical significance（ P〈0. 05）. Conclusion Through ROC curve analysis,CK19- 2G2 for the diagnosis of malignant tumor is better than Cyfra21-1,the diagnostic accuracy of 2 markers combined detection is higher than single marker detection. The CK19- 2G2 can be used as an aid in the management of patients with suspected or confirmed malignant tumor.

关 键 词：细胞角蛋白19-2G2 非小细胞肺癌相关抗原21-1 恶性肿瘤 诊断 

分 类 号：R73-3[医药卫生—肿瘤]