Phystcal performance and life quality in postmenopausal women supplemented with vitamin D： a two-year prospective study  

作　　者：Li-hong GAO Wen-jun ZHU Yu-juan LIU Jie-mei GU Zhen-lin ZHANG Ou WANG Xiao-ping XING Ling XU 

机构地区：[1]Metabolic Bone Diseases and Genetic Research Unit, Department of Osteoporosis and Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, Chinal [2]Department of Endocrinology, Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China [3]Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

出　　处：《Acta Pharmacologica Sinica》2015年第9期1065-1073,共9页中国药理学报（英文版）

摘　　要：Aim： To investigate the effects of calcium and vitamin D supplementation on bone turnover marker levels, muscle strength and quality of life in postmenopausal Chinese women. Methods： A total of 485 healthy postmenopausal Chinese women （63.44±5.04 years） were enrolled in this open-label, 2-year, prospective, community-based trial. The participants were divided into group A, B, C, which were treated with calcium （600 mg/d） alone, calcium （600 mg/d） and cholecalciferol （800 IU/d） or calcium （600 mg/d） and calcitriol （0.25 pg/d）, respectively, for 2 years. Serum levels of 25-hydroxyvitamin D, parathyroid hormone, 13-CTX and PINP were measured, and the muscle strength and quality of life were assessed at baseline and at 12- and 24-month follow-ups. Results： Four hundred and sixty one participants completed this study. Serum levels of 25-hydroxyvitamin D were significantly increased in group C, but not changed in groups A and B at 24-month follow-up. Serum levels of parathyroid hormone, bone turnover marker β-CTX and bone formation marker PINP were significantly decreased in group C, while serum levels of β-CTX were increased in group A at 24-month follow-up. The participants in group C maintained the grip strength, while those in groups A and B exhibited decreased grip strength at 24-month follow-up. The quality of life for the participants in groups B and C remained consistent, but that in group A was deteriorated at 24-month follow-up. Conclusion： Supplementation with calcitriol and calcium modifies the bone turnover marker levels, and maintains muscle strength and quality of life in postmenopausal Chinese women, whereas supplementation with cholecalciferol and calcium prevents aging-mediated deterioration in quality of life.Aim： To investigate the effects of calcium and vitamin D supplementation on bone turnover marker levels, muscle strength and quality of life in postmenopausal Chinese women. Methods： A total of 485 healthy postmenopausal Chinese women （63.44±5.04 years） were enrolled in this open-label, 2-year, prospective, community-based trial. The participants were divided into group A, B, C, which were treated with calcium （600 mg/d） alone, calcium （600 mg/d） and cholecalciferol （800 IU/d） or calcium （600 mg/d） and calcitriol （0.25 pg/d）, respectively, for 2 years. Serum levels of 25-hydroxyvitamin D, parathyroid hormone, 13-CTX and PINP were measured, and the muscle strength and quality of life were assessed at baseline and at 12- and 24-month follow-ups. Results： Four hundred and sixty one participants completed this study. Serum levels of 25-hydroxyvitamin D were significantly increased in group C, but not changed in groups A and B at 24-month follow-up. Serum levels of parathyroid hormone, bone turnover marker β-CTX and bone formation marker PINP were significantly decreased in group C, while serum levels of β-CTX were increased in group A at 24-month follow-up. The participants in group C maintained the grip strength, while those in groups A and B exhibited decreased grip strength at 24-month follow-up. The quality of life for the participants in groups B and C remained consistent, but that in group A was deteriorated at 24-month follow-up. Conclusion： Supplementation with calcitriol and calcium modifies the bone turnover marker levels, and maintains muscle strength and quality of life in postmenopausal Chinese women, whereas supplementation with cholecalciferol and calcium prevents aging-mediated deterioration in quality of life.

关 键 词：postmenopausal women CHOLECALCIFEROL CALCITRIOL 25-hydroxyvitamin D parathyroid hormone β-CTX PINP bone turnover muscle strength quality of life 

分 类 号：S831.5[农业科学—畜牧学] F126[农业科学—畜牧兽医]