^1H-MRS评价颞叶癫痫患者杏仁核代谢物比值  

^1H-MRS evaluation of metabolite ratios of amygdala in temporal lobe epilepsy patients

作　　者：肖翔[1] 许乙凯[1] 代月黎[2] 李维粤[1] 陈婉琪[1] 吴元魁[1] 

机构地区：[1]南方医科大学南方医院影像中心,广州510515 [2]南华大学附属第二医院放射科,衡阳421001

出　　处：《中国医学影像技术》2015年第9期1300-1303,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的采用1 H-MRS探讨颞叶癫痫(TLE)患者双侧杏仁核的各代谢物比值改变。方法对15例TLE患者(TLE组)和15名健康志愿者(正常对照组)行杏仁核1 H-MRS扫描,比较两组杏仁核的N-乙酰天门冬氨酸(NAA)/[胆碱复合物(Cho)+肌酸(Cr)]、NAA/Cr、NAA/Cho和Cho/Cr比值,分析TLE患者双侧杏仁核各代谢物比值与癫痫病程和发病年龄的相关性。结果 TLE组患侧杏仁核NAA/(Cho+Cr)和NAA/Cr比值与正常对照组比较均明显减低(P均<0.05);TLE组患侧杏仁核NAA/(Cho+Cr)、NAA/Cr、NAA/Cho和Cho/Cr比值与TLE组对侧比较差异均无统计学意义(P均>0.05);TLE组对侧杏仁核NAA/(Cho+Cr)、NAA/Cr和NAA/Cho比值与正常对照组比较均明显减低(P均<0.05)。TLE组双侧杏仁核NAA/(Cho+Cr)、NAA/Cr和NAA/Cho比值与癫痫病程及发病年龄均无相关性(P均>0.05)。结论 TLE患者双侧杏仁核存在显著的代谢异常,双侧杏仁核可能作为传导通路的一个环节,参与TLE的发病过程。Objective To investigate the metabolite ratios changes of bilateral amygdala in TLE patients with 1 H-MRS.Methods Fifteen TLE patients（TLE group）and 15 healthy volunteers（control group）were performed 1 H-MRS of amygdala.The ratios of N-acetylaspartate（NAA）/（choline [Cho]＋ creatine [Cr]）,NAA/Cr,NAA/Cho and Cho/Cr of amygdala between two groups were compared.The correlation between the duration of epilepsy,the age of onset and the ratios of NAA/（Cho＋Cr）,NAA/Cr and NAA/Cho in bilateral amygdala of TLE group were analyzed.Results The ratios of NAA/（Cho＋Cr）and NAA/Cr in ipsilateral amygdale of TLE group were significant lower than those of control group（both P〈0.05）.There were no significant differences in the ratios of NAA/（Cho＋Cr）,NAA/Cr,NAA/Cho or Cho/Cr between bilateral amygdala of TLE group（all P〉0.05）.The ratios of NAA/（Cho＋Cr）,NAA/Cr and NAA/Cho in the contral lateral amygdale of TLE group was significant lower than those of control group（all P〈0.05）.The ratios of NAA/（Cho＋Cr）,NAA/Cr and NAA/Cho in bilateral amygdala of TLE group had no correlation with the duration of epilepsy or the age of onset（all P〉0.05）.Conclusion TLE patients have significant metabolic changes in bilateral amygdala,and bilateral amygdala may serve as a link of the conductive pathway,involving in the pathogenesis of TLE.

关 键 词：颞叶 癫痫 杏仁核 磁共振波谱成像 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]