视网膜色素变性患眼黄斑中心凹下脉络膜厚度与视功能的相关性分析  

Correlation of choroidal thickness and visual function in retinitis pigmentosa patients

作　　者：张红[1] 罗英子 宋柯[1] 张津京[1] 杨佳[1] 袁敏立[1] 孟宁[1] 范洋[1] 庄曾渊[1] 

机构地区：[1]中国中医科学院眼科医院检查中心,北京100040

出　　处：《中华眼底病杂志》2015年第5期435-438,共4页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的观察分析视网膜色素变性（RP）患眼黄斑中心凹下脉络膜厚度（SCT）及其与视功能的相关性。方法I临床确诊的RP患者42例84只眼（RP组）以及与之年龄、屈光度相匹配的正常健康者49名98只眼（正常对照组）纳入研究。采用光相干断层扫描的增强深部成像技术测量受检眼的SCT。以年龄为协变量，对年龄与组别的交互作用行协方差分析，并对两组受检眼SCT进行修正。RP组患眼同时行视网膜电图（ERG）和OCTOPUS自动视野计T32或LVC程序30。视野检查。84只眼中，接受T32程序检查32只眼；因中心视力较差、有固视障碍者接受LVC程序检查52只眼。记录RP患眼ERG波形及视野平均敏感度（MS）、平均缺损（MD）值。观察不同ERG波形表现者、接受不同视野程序检查者的SCT。采用Pearson相关性分析法分析RP患眼SCT与MS、MD值的关系。结果RP组、正常对照组受检眼SCT分别为（223．12±69．59）、（288．29±52．36）μm。协方差分析结果显示，年龄与组别之间无交互作用（F=1．619，P=0．205）。RP组、正常对照组受检眼修正后的SCT分别为（217．34±6．60）、（293．20±6．00）μm。RP组患眼SCT较正常对照组受检眼明显降低，差异有统计学意义（t=7．042，P〈0．001）。RP组84只眼中，明视视锥反应波形减弱35只眼，波形平坦49只眼；暗视视杆反应波形减弱31只眼，波形平坦53只眼。不同ERG波形患眼的SCT比较，差异均无统计学意义（t=-0．976、-1．584，P=0．332、0．117）。接受T32程序视野检查者MS、MD值分别为（9．05±6．42）、（18．84±6．30）dB，SCT为（209．83±71．48）“m。接受I。VC程序视野检查者MS值为（7．14±5．03）dB，SCT为（228．32±66．32）μm。相关性分析结果显示，接受T32程序视野检查患眼的SCT与MS值呈正相关（r=0．494，P=0．003），与MD值呈负相关（r=-0．448，P：0．009）。接受LVC程序视Objective To analyze the subfoveal choroidal thickness in retinitis pigmentosa （RP） patients and to evaluate the correlation between the subfoveal choroidal thickness （SCT） and visual function. Methods Totally 42 RP patients （84 eyes） and 49 age and diopter-matched normal controls （98 eyes） were enrolled in this study. All the patients were taken the enhanced depth imaging technique of optical coherence tomography （EDI-OCT） examination for the measurement of the SCT. The covariate analysis was used to analyze the interaction effect between age and group. Then the SCT was amended. The RP patients were examined by 30~visual field test （T32 or LVC program） and electroretinogram （ERG） test. 32 eyes examined by T32 program, 52 eyes examined by LVC program. The waveform of ERG, mean sensitivity （MS） and mean defect （MD） were recorded. The relationship of SCT, MS and MD were analyzed by Pearson correlation analysis. Results The SCT of RP patients and controls were （223.12 ± 69.59）, （288.29±52.36） μm. The covariate analysis of covariance with different age group interaction was not statistically significant （F= 1. 619, P= 0. 205）, as amended SCT of RP patients and controls were （217.34 ±4 6.60）, （293.20±6.00） μm, respectively. The SCTwas decreased in RP patients （t=.042,P=0. 001）. Among 84 eyes, bright cone response weaken in 35 eyes, scotopic rod response weaken in 31 eyes. Thedifference of SCT in different ERG waveform was not significant （t =- 0. 976, -1. 584; P = 0. 332, 0. 117）. The MS and MD of 32 eyes using T32 program were （9.05±6.42）, （18.84±6.30） dB, the SCT was （209.83±71.48） ttm; the MS and SCT of 52 eyes using LVC program were （7.14±5.03） dB and （228.32±66.32） μm. The SCT was related to MS （r=0.494,P=0.003） and MD （r=-0.448,P= 0. 009） in eyes using T32 program. There was no correlation between SCT and MD in eyes using LVC program （r=- 0. 232, P= 0. 095）. Conclusions The SCT of RP patients is thinner th

关 键 词：色素性视网膜炎/并发症 脉络膜 视觉障碍/病因学 体层摄影术 光学相干 

分 类 号：R774.1[医药卫生—眼科]