中医药治疗鼻咽癌患者放射性口腔干燥症临床效果的系统评价  

Clinical Effectiveness of Chinese Medicine in Treating Nasopharyngeal Carcinoma Patients with Radioactive Xerostomia: A Systematic Review

作　　者：陈佩仪[1] 王谨[1] 刘彬[1] 张慧敏[1] 邵珍珍[1] 李玉洁[1] 

机构地区：[1]广州中医药大学,广东广州510006

出　　处：《广州中医药大学学报》2015年第5期848-852,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省自然科学基金资助项目(编号:2060203)

摘　　要：【目的】评价中医药治疗鼻咽癌患者放射性口腔干燥症的临床疗效。【方法】采用计算机检索方式检索中文数据库中国期刊网(CNKI)、万方学术期刊数据库、维普中文期刊数据库(VIP)、中国生物医学文献服务系统(CBM)及英文数据库Cochrane Library、JBI Library、Pub Med、OVID、EMBase、Web of Science,结合手工检索筛选关于中医药治疗鼻咽癌患者放射性口腔干燥症的随机及半随机对照研究。由两名研究者独立对文献进行质量评价和资料提取,对符合纳入标准的文献进行Meta分析。【结果】纳入的8篇研究的Meta分析结果显示,中医药治疗能有效延迟鼻咽癌放疗患者口腔黏膜反应分级的病程进展,减少3、4级口腔黏膜反应的发生率(Z=4.86,P<0.000 01)。【结论】中医药治疗鼻咽癌患者放射性口腔干燥症疗效确切,值得临床推广使用。Objective To systematically review the clinical effectiveness of Chinese medicine in treating nasopharyngeal carcinoma patients with radioactive xerostomia. Methods The randomized or semi-randomized controlled trials of the Chinese medicine for nasopharyngeal carcinoam patients with radioactive xerostomia were screened out by online retrieving and manual retrieving of domestic and oversea databases such as Cochrane Library, JBI Library, PubMed, OVID, EMBase, Web of Science, CNKI, Wanfang Database, VIP Database, CBM Database. The data extract and quality assessment were performed by two reviewers independently. Meta-analysis was conducted for the included trials. Results Eight trials were included. The results of Meta-analysis showed that Chinese medicine can effectively delay the progress of oral mucous membrane ulcer in nasopharyngeal carcinoma patients after radiotherapy, and decrease the incidence of grade 3-4 oral mucous membrane ulcer （ Z=4.86, P〈0.00001） . Conclusion Chinese medicine has certain effect in treating nasopharyngeal carcinoma patients with radioactive xerostomia.

关 键 词：鼻咽癌/中药疗法 放射性口腔干燥症 系统评价 

分 类 号：R739.63[医药卫生—肿瘤]