赣州市唇腭裂孕妇血浆代谢组学的初步分析  

Preliminary Analysis of Metabonomics of Pregnant Women with Cleft Lip and Palate Fetus in Ganzhou City

作　　者：凌永昌[1] 刘翔[1] 张莹[1] 刘新征[1] 李年生[1] 

机构地区：[1]赣南医学院第一附属医院,江西赣州341000

出　　处：《中国医学创新》2015年第27期12-15,共4页Medical Innovation of China

基　　金：江西省卫生厅科技计划(20141116)

摘　　要：目的:探讨唇腭裂孕妇血浆代谢组学特点,为临床早期检测唇腭裂胎儿提供诊断依据。方法:选取2014年2月-2015年4月本院产前超声筛查诊断胎儿为唇腭裂的孕妇21例作为病例组,随机选取同期本院产前筛查诊断胎儿为正常的孕妇21例作为对照组,采用基于核磁共振(NMR)的代谢组学技术分别检测并比较两组孕妇血浆代谢组学特点。结果:病例组血浆代谢产物与对照组有显著差异,病例组患者血浆中苯丙氨酸、缬氨酸和酪氨酸含量高于对照组,而丙氨酸、胆碱、磷酰胆碱代谢产物较对照组含量降低。结论:基于NMR代谢组学技术可较好反映唇腭裂胎儿孕妇血浆代谢变化,能获得相应特征代谢物,有重要临床应用前景。Objective：To investigate the metabonomics features of pregnant women with cleft lip and palate fetus in order to provide diagnostic evidences for the early detection of fetus with cleft lip and palate.Method：21 pregnant women who were diagnosed with cleft lip and palate fetus through prenatal ultrasound screening in our hospital from February 2014 to April 2015 were selected as the case group,21 normal pregnant women who received the prenatal ultrasound screening in our hospital were randomly selected as the control group at the same time.The metabonomics features of the two groups were detected through metabonomics technology based on the nuclear magnetic resonance （NMR）.The metabonomics features of the two groups were compared.Result：The plasma metabolites of the two groups were significantly different.The contents of phenylalanine,valine and tyrosine in the case group were higher than those in the control group.The contents of alanine,choline and phosphorylcholine in the case group were lower than those in the control group.Conclusion：NMR-based metabonomics can well reflect the metabolic changes in pregnant women with cleft lip and palate fetus.It can obtain corresponding metabolites features and has important clinical application prospect.

关 键 词：唇腭裂 孕妇 血浆 代谢组学 

分 类 号：R782.2[医药卫生—口腔医学]